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Network pharmacology and experimental verification reveal the mechanism of hederagenin in suppressing podocyte injury in focal segmental glomerular sclerosis

Paper D Peer reviewed Preclinical

Key takeaways

Researchers tested hederagenin, a plant compound, to see if it could protect the kidney's filter cells in a scarring disease called FSGS. In lab tests it seemed to reduce damage to those cells. This was done in cells and lab models, not in people, so it is only an early signal.

Who did this work

Xiyue Tian · Rangyue Han · Xiaojiao Gu · Yuqing Li · Honglian Wang · Qiongdan Hu · Li Wang

Source

Paper · OpenAlex, CKD concept sweep (DB seed + weekly delta) · 2026-08-10
https://doi.org/10.5414/cn111952