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Real-world effectiveness and safety of difelikefalin for chronic kidney disease-associated pruritus: a systematic review.

Article C Peer reviewed Observational

Key takeaways

This review gathered real-world reports on difelikefalin, a drug for the severe itch that kidney disease can cause. It looked at how well the drug worked and how safe it was outside of trials. Because it pools everyday-use data rather than randomized trials, it shows a link and not firm proof.

Who did this work

Sheldon R · Wadodkar M · Gan A · Chien HY · Baharani J

Source

Article · PubMed, Lifestyle and CKD · 2026 Aug 11
https://pubmed.ncbi.nlm.nih.gov/42576770/