← brief for 2026-08-13 · Slowing decline
Discovery of 2, 4-disubstituted pyrimidine derivatives as selective HIPK2 inhibitors for potential treatment of chronic kidney disease.
Key takeaways
In mice with CKD: three compounds showed potential to inhibit the kinase HIPK2, which drives fibrosis. Results not yet in humans.
Who did this work
Hu X · Ouyang H · Feng C · Wu Y · Yao M · Xu J · Chen Z · Li Q
Source
Article · PubMed, CKD progression and prevention · 2026 Aug 10
https://pubmed.ncbi.nlm.nih.gov/42594677/