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Elevated 5-oxoproline levels and adverse outcomes in heart failure: Association with renal cortical OPLAH loss in a multi-comorbidity model.

Article B Peer reviewed Small trial

Key takeaways

High levels of 5-oxoproline in blood linked to kidney failure. This US trial with 823 patients found that low levels of the enzyme OPLAH increase risk. This may affect how cells handle oxidative stress.

Who did this work

Esquivel-Gaytan A · Al-Mubarak AA · Sorop O · Merkus D · Voors AA · Silljé HHW · Duncker DJ · van der Meer P · Bomer N

Source

Article · PubMed, CKD severity and reversal · 2026 Aug 17
https://pubmed.ncbi.nlm.nih.gov/42612422/