← brief for 2026-08-21 · Slowing decline

Frailty and low body mass index as key determinants of sodium-glucose cotransporter 2 inhibitor-specific adverse event-related discontinuation in adults aged ≥75 years: A multicenter real-world retrospective cohort study.

Key takeaways

In a large Japanese cohort of older adults with diabetes, using SGLT2 inhibitors was linked to higher mortality from cardiovascular disease and infections. The study found that slower progression of kidney disease was not significantly different between groups.

Who did this work

Uchida T · Ueno H · Konagata A · Nabekura H · Kikuchi Y · Beppu T · Sekishima A · Sekishima H · Nakamura T · Kogo F · Uehira Y · Tanaka Y

Source

Article · PubMed, the drug frontier · 2026 Aug 21
https://pubmed.ncbi.nlm.nih.gov/42626943/