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The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation with Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: The HELI Randomised Controlled Trial

Key takeaways

A trial of a multi-domain lifestyle intervention in older adults with kidney disease is ongoing. The study aims to see if better nutrition and activity can slow cognitive decline.

Who did this work

van Loenen MR (Centre for Cognitive Neuroimaging, , , ,) · Zwart NR (Division of Human Nutrition and Health, , ,) · Remie LB (Centre for Cognitive Neuroimaging, , , ,) · van Trijp MP (Division of Human Nutrition and Health, , ,) · Jansen MG (Centre for Cognition, , , ,) · Marques JP (Centre for Cognitive Neuroimaging, , , ,) · Claassen JA (Department of Geriatrics, , , ,) · Grootte Bromhaar MM (Division of Human Nutrition and Health, , ,) · van de Rest O (Division of Human Nutrition and Health, , ,) · Verberk IM (Neurochemistry Laboratory, Department of Laboratory Medicine, , , , ,) · Vermeiren Y (Division of Human Nutrition and Health, , ,) · Hooiveld GJ (Division of Human Nutrition and Health, , ,)

Source

Paper · Europe PMC, CKD mind-body · 2026-07-29
https://doi.org/10.64898/2026.07.28.26358647