← brief for 2026-08-27 · Slowing decline

Clinical Spectrum and Early Renal Functional Variability in a Nationwide Greek Pediatric HNF1B Multicenter Cohort

Key takeaways

HNF1B is a gene that, when altered, can cause kidney problems present from birth. Centers across Greece pooled their children with this gene change and described the range of symptoms and how kidney function moved in the early years. This is an observational cohort, so it describes patterns rather than proving what drives them. For families with this diagnosis it gives a clearer picture of what outcomes to expect.

Who did this work

John Dotis (Aristotle University of Thessaloniki) · Argyroula Zampetoglou (Panagiotis & Aglaia Kyriakou Children's Hospital) · Varvara Askiti (Panagiotis & Aglaia Kyriakou Children's Hospital) · María Bitsori (University Hospital of Heraklion) · Ekaterini Siomou (University Hospital of Ioannina) · Chrysoula Kosmeri (University Hospital of Ioannina) · Nikoleta Printza (Aristotle University of Thessaloniki) · Antonia Kondou (Aristotle University of Thessaloniki) · Athina Ververi (Papageorgiou General Hospital) · Charalampos Kapogiannis (Athens Medical Center) · Anastasios Kapogiannis (Iaso Children’s Hospital) · Despoina Tramma (Papageorgiou General Hospital)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-26
https://doi.org/10.3390/jcm15176590