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Association between α-klotho and frailty progression at dialysis initiation: a prospective cohort study

Paper C Peer reviewed Observational

Key takeaways

In 212 people starting dialysis, lower levels of a protein called α-klotho were linked to faster frailty worsening over one year. Because this is an observational study, it shows a link but not proof that raising α-klotho would help.

Who did this work

Yuma Hirano (Hamamatsu University Hospital) · Tomoyuki Fujikura (Hamamatsu University Hospital) · Tomoya Yamaguchi (Hamamatsu University Hospital) · Kenichi Kono (Fukuoka International University) · Akihiko Kato (Hamamatsu University Hospital) · Naro Ohashi (Hamamatsu University Hospital) · Tomoya Omura (Hamamatsu University Hospital) · Tetsuyuki Nagafusa (Hamamatsu University Hospital) · Katsuya Yamauchi (Hamamatsu University Hospital) · Hideo Yasuda (Hamamatsu University Hospital)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-27
https://doi.org/10.1186/s12882-026-05319-9