← brief for 2026-08-29 · Slowing decline

Phosphodiesterase 4 Inhibitor Roflumilast Ameliorates Polytrauma-Induced Acute Kidney Injury by Attenuating HMGB1 and Renal Inflammatory Pathways in Rats

Paper D Peer reviewed Preclinical

Key takeaways

In rats with multiple injuries, a drug called roflumilast lowered kidney inflammation and helped protect the kidneys by blocking a protein called HMGB1. This was tested only in animals — not people yet.

Who did this work

Caroline Gusson Shimoura · Dustin M. Kneifel · Heaven D. Sessions · Jeanette Rocha · Kassandra Gonzalez · Emily M. Corbin · Venkata Yellepeddi · Brian Kirkwood · Jose Salinas · Andrew D. Meyer · Zhangsheng Yang

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-28
https://doi.org/10.3390/ijms27177696