← brief for 2026-08-29 · Slowing decline

Uremic Serum Alters Gene Expression Profiles and Signaling Pathway Activity in Porcine Arterial Smooth Muscle Cells

Key takeaways

In pig artery cells in the test tube, blood from people with end-stage kidney disease changed which genes were active and how signaling pathways worked—this suggests uremic toxins may harm blood vessels, but it has not been tested in people yet.

Who did this work

Youyou Zheng (University of North Carolina at Chapel Hill) · Kenton Lee (University of North Carolina at Chapel Hill) · Unimunkh Uriyanghai (University of North Carolina at Chapel Hill) · Christine Wai (University of North Carolina at Chapel Hill) · Mihaela Mocanu (University of North Carolina at Chapel Hill) · Anthony Z. Yang (University of North Carolina at Chapel Hill) · Huanjuan Su (University of North Carolina at Chapel Hill) · Lianxia Li (University of North Carolina at Chapel Hill) · Vinay A. Sudarsanam (University of North Carolina at Chapel Hill) · John S. Poulton (University of North Carolina at Chapel Hill) · Prabir Roy-Chaudhury (University of North Carolina at Chapel Hill) · Gang Xi (University of North Carolina at Chapel Hill)

Source

Paper · OpenAlex, CKD works · 2026-08-28
https://doi.org/10.3390/biom16091252