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Kidney research, 2026-09-12

Today brought background science on kidney protection, not new results to act on.

Key takeaways

Today's sweep was light, and most of it explained how things work rather than showing what happens to patients. The one high grade item with hard outcomes was a summary of past SGLT2 inhibitor trials, which is worth knowing if you and your doctor have discussed those drugs, but it is not new evidence. The blood pressure review points in a helpful direction without giving a size to the benefit. Two transplant studies and a gum disease study rounded out the day, all observational, meaning they spot patterns rather than prove causes.

Slowing decline 路 8

鹿鈦封伔Lu-PSMA Radioligand Therapy in Metastatic Castration-resistant Prostate Cancer With Complex Renal Conditions: A Case Series.

Doctors treated men with advanced prostate cancer using a radioactive drug, Lu-177 PSMA, that the kidneys clear from the body. These men also had kidney problems, so they are...

Paper C Peer reviewed Europe PMC, CKD 路 added 6 days ago

Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes.

Researchers measured blood proteins in 273 Hispanic and Latino children and teens, average age about 13, and matched them to 25 early signs of trouble in the liver, body fat, blood...

Article C Peer reviewed PubMed, the drug frontier 路 added 6 days ago

Shenqi Yanshen Decoction protects against renal and bone injury in chronic kidney disease-mineral and bone disorder with potential involvement of Wnt5a/RhoA/Pkn3 signaling.

A traditional Chinese herbal mix called Shenqi Yanshen Decoction was tested against the kidney and bone damage that often comes with chronic kidney disease. The work was done in...

Article D Peer reviewed PubMed, fibrosis reversal 路 added 6 days ago

Targeting ITIH3 inhibits oxidative stress and autophagy in renal tubular epithelial cells by regulating the HSP90B1/STAT3 axis, thereby alleviating diabetic nephropathy injury.

ITIH3 is a blood protein that runs high in people with kidney damage from diabetes. Researchers blocked it in diabetic mice and in kidney tubule cells grown in the lab. Blocking it...

Article D Peer reviewed PubMed, fibrosis reversal 路 added 6 days ago

SGLT2 Inhibitors as Potential Agents for Prevention, Treatment, and/or Improved Recovery from Acute Kidney Injury.

This review asks whether SGLT2 inhibitors, drugs that make the kidneys pass sugar out in urine, could prevent or speed recovery from sudden kidney failure (acute kidney injury)....

Article D Not peer reviewed PubMed, the drug frontier 路 added 6 days ago

Type 2 Diabetes: Chronic Clinical Metabolic Effects of SGLT2 Inhibitors.

This review chapter sums up what SGLT2 inhibitor drugs do over the long run in people with type 2 diabetes. It draws on large randomized trials with hard outcomes like kidney...

Article A Not peer reviewed PubMed, the drug frontier 路 added 6 days ago

Clinical Physiology of SGLT2 Inhibitors in Non-diabetic and Diabetic Individuals.

This review explains how SGLT2 inhibitor drugs work inside the body, in people with diabetes and people without it. The drug acts on one small part of the kidney, the proximal...

Article C Not peer reviewed PubMed, the drug frontier 路 added 6 days ago

SGK2 Promotes NEDD4L-Mediated ACSL4 Ubiquitination to Inhibit Ferroptosis and Alleviate Diabetic Kidney Disease.

Even with today's best diabetes drugs, kidney tubules keep getting damaged, and one cause is a form of cell death driven by iron (ferroptosis). This study found that an enzyme...

Article D Peer reviewed PubMed, the drug frontier 路 added 6 days ago
Nutrition & lifestyle 路 1

Effectiveness of culturally adapted lifestyle intervention package on blood pressure: A systematic review.

Researchers searched five large medical databases for lifestyle programs built to fit people's own culture, mixing food changes, exercise and behavior support. They then judged how...

Paper A Peer reviewed Europe PMC, CKD mind-body 路 added 6 days ago
Mind-body 路 3

Impact of a Residential Yoga and Naturopathy-based Lifestyle Modification on Cardio-Metabolic Risk Factors in Patients with Hypertension: A Retrospective Study.

Researchers looked back at records of people with high blood pressure who stayed at a live-in center doing yoga and naturopathy, and compared heart and metabolic numbers before and...

Paper C Peer reviewed Europe PMC, CKD mind-body 路 added 6 days ago

Prevalence and Factors Associated with Depression and Anxiety in Patients with Chronic Kidney Disease.

Researchers checked 107 people on dialysis for depression and anxiety, 67 on hemodialysis and 40 on peritoneal dialysis, using a standard questionnaire. They then looked at which...

Article C Peer reviewed PubMed, Lifestyle and CKD 路 added 6 days ago

A Multimodal Lifestyle and Mind-Body Intervention in Rural Primary Care: Implications for Metaflammation in an Appalachian Population.

This describes a program in rural Appalachian primary care that pairs lifestyle changes with mind-body practice. The target is long-running low-level inflammation, sometimes called...

Article No results yet Peer reviewed PubMed, CKD mind-body (BP/sympathetic) 路 added 6 days ago
Transplant & xeno 路 2

Prevalence and Systemic Factors Associated with Periodontitis among Kidney Transplant Recipients: A Cross-sectional Study in Vietnam.

Researchers in Vietnam checked how common gum disease (periodontitis) is in people living with a kidney transplant, and what goes along with it. Transplant patients take drugs that...

Article C Peer reviewed PubMed, CKD progression and prevention 路 added 6 days ago

Delayed Graft Function After Simultaneous Heart-Kidney Transplantation Across Heart Allocation Eras: Predictors and Impact on Kidney Graft Survival in a National Cohort.

This national study looked at people who received a heart and a kidney in the same operation. It asked what makes the new kidney slow to start working, called delayed graft...

Article C Peer reviewed PubMed, CKD severity and reversal 路 added 6 days ago