← brief for 2026-08-15 · Slowing decline

AMPK-OXSR1 signaling coordinates proximal tubular sodium transport and is modulated by canagliflozin.

Article D Peer reviewed Preclinical

Key takeaways

This study in human and rat kidney cells found that the WNK/OXSR1 pathway regulates sodium transport in proximal tubules. This could be a target for drugs to slow kidney damage.

Who did this work

Nakamura M · Seki G · Satoh N · Takagi M · Mizuno T · Tsukada H · Horita S · Sato Y · Kume H · Nangaku M

Source

Article · PubMed, the drug frontier · 2026 Jul 31
https://pubmed.ncbi.nlm.nih.gov/42601929/