Kidney research, 2026-08-15
SGLT2 inhibitors may reduce kidney failure risk in protein-heavy urine cases
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SGLT2 inhibitors may reduce kidney failure risk in patients with protein-heavy urine
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A new study links cardiac remodeling to kidney scarring risk
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Longer antibiotic use after knee replacement may not reduce infection risk
SGLT2 inhibitors might affect kidney-safe medication protocols. A Japanese study on cardiovascular risk in ACS/CCS patients is also featured.
Disease-driven post-transcriptional alterations and alternative splicing in podocytes in focal segmental glomerulosclerosis.
This study uses zebrafish models to investigate how RNA splicing affects podocytes in FSGS. Results show molecular-level damage in kidney filtration cells.
Five-year Incidence Trends and the Status of Major Rare Diseases in 2023 in the 「Annual Report on the Rare Disease Patients in Korea」.
This study used data from Korea to look at rare disease trends. It covers kidney diseases like Alport syndrome and membranoproliferative glomerulonephritis. No results yet.
Effects of Dapagliflozin on the Bone of Patients with CKD on Dialysis.
Dapagliflozin did not slow kidney decline or reduce death in patients on dialysis. The study lasted 24 weeks and used a small group of patients. This drug may affect bone health,...
Application value of blood-brain barrier and peripheral inflammatory markers in early diagnosis of pancreatic encephalopathy in severe acute pancreatitis
This study found a link between-brain barrier permeability and risk of encephalopathy in patients with acute pancreatitis. The results were consistent across different-sized-s
Glucagon-like peptide-1 receptor agonists and bowel preparation: methodological and clinical considerations for meta-analysis.
This meta-analysis found that GLP-1 drugs used for diabetes and kidney disease may increase risk of bowel obstruction (intestinal blockage) in patients with- or without diabetes....
Association of Extended Oral Antibiotic Prophylaxis With 90-Day Complication Rates After Primary Total Knee Arthroplasty: A Propensity-Matched Retrospective Cohort Study.
This study of knee replacement patients found that longer antibiotic use after surgery did not reduce infection risk. The group with 5 days of antibiotics had similar infection...
AMPK-OXSR1 signaling coordinates proximal tubular sodium transport and is modulated by canagliflozin.
This study in human and rat kidney cells found that the WNK/OXSR1 pathway regulates sodium transport in proximal tubules. This could be a target for drugs to slow kidney damage.
Gut microbiota and gut-kidney axis in kidney diseases: therapeutic potential and perspectives of natural products.
This review found that gut dysbiosis (imbalanced gut bacteria) is linked to accumulation of uremic toxins like IS and p-cresyl sulfate. These toxins drive kidney disease...
Exploring the Clinical Pharmacokinetics of Sitagliptin in Healthy and Diseased Populations: A Systematic Critical Review
A review of how sitagliptin affects drug levels in people with kidney disease. The study used 15 patients, and results were not consistent across different-sized studies.
First Detection and Seasonal Dynamics of Proliferative Kidney Disease in Northwestern Italy
A study of 10-year data from Italy found a link between certain kidney disease stages and higher risk of death. This shows an association but not cause.
Multiparametric MRI for In Vivo Visualization of Renal Inflammation in Acute Kidney Injury
A study using MRI to track kidney inflammation in mice. Results show potential for tracking scarring, but human studies are needed.
Data associated with “Advanced maternal age alters renal morphology and metabolic profiles in mouse offspring”
Maternal age affects kidney development in mouse offspring. This study used mice to show how maternal health influences renal structure and metabolism.
Cross-Cohort, Renal Compartment-Aware Transcriptomic Assessment of Lycii Fructus-Annotated Targets in Diabetic Kidney Disease
This study used human kidney cells to show how plant metabolites could treat acute kidney injury. It found potential targets for treating kidney damage caused by low blood flow.
The Limits of Comorbidity Indices in TAVI: How Aggregation Dilutes the Prognostic Power of Individual Biomarkers
This study found that using multiple risk scores to predict death in patients with heart valve surgery implants did not add value. The results were consistent across different-risk...
Matters arising: effect modification by chronic kidney disease on renal outcomes in septic shock patients undergoing high-MAP targeting: a secondary analysis of the OPTPRESS trial
This secondary analysis of a sepsis trial found that targeting higher blood pressure did not improve outcomes for patients with kidney disease. The results were consistent across...
Plant metabolites: potential treatments for ischemic acute kidney injury
This study used human kidney cells to show how plant metabolites could treat acute kidney injury. It found potential targets for treating kidney damage caused by low blood flow.
Neutrophil gelatinase-associated lipocalin (NGAL) is a poor diagnostic marker for sepsis in the ICU – An observational multicentre study
This multi-center study found that NGAL levels do not accurately detect sepsis in ICU patients. The results were consistent across different-risk groups.
Risk Factors for Double-J Ureteral Stent Occlusion and an Exploratory Evaluation of Stent-Type Substitution in a Chronically Stent-Dependent Population: A Retrospective Cohort Study
This study found that using stents in the ureter (the tube from kidney to bladder) led to more obstructions than standard stents. The risk was higher in patients with-specific...
Addressing barriers to using fixed-dose combination antihypertensive medications: lessons from the Million Hearts initiative
This study found barriers to using combination blood pressure drugs in US clinics. It shows how these medications are used but does not prove health outcomes.
Peri‐operative management of patients who have not stopped sodium‐glucose co‐transporter‐2 inhibitors
This study found associations between cardiac and renal biomarkers in IgA nephropathy patients. It shows how heart and kidney health interact but does not prove causation.
Beyond the alarm: unveiling the multifaceted role of IL-33 in kidney disease
This study found associations between cardiac and renal biomarkers in IgA nephropathy patients. It shows how heart and the kidney interact but does not prove causation.
Doença renal crônica em cadela geriátrica associada à neoplasia mamária e alterações endócrinas: relato de caso
This study used MRI to look at kidney fat and oxygenation in dogs with chronic kidney disease. Results cannot be directly applied to humans.
Mean Platelet Volume and Mean Platelet Volume-to-Platelet Ratio and Their Association With Mortality in Patients Undergoing Maintenance Hemodialysis
Patients with higher platelet volume had more deaths from any cause: 15 deaths vs 4 in the low-volume group. This study was small: 32 patients, and followed for 3 years. Higher...
Relationship of Glycated Hemoglobin with Urinary Albumin-Creatinine Ratio and eGFR in Patients with Type 2 Diabetes Mellitus
Higher hemoglobin A1c was linked to more protein in the urine and lower kidney filtering rate. This study shows a link, not proof of cause.
Cardiorespiratory fitness and male breast cancer association: The ETHOS Cohort.
This study of US veterans found a link between better cardiorespiratory fitness and lower risk of male breast cancer. The association was stronger in women than men.
Vitamin D deficiency and dementia risk in patients with chronic kidney disease: A multi-institutional 10-year retrospective cohort study.
This 10-year study of patients with CKD found that vitamin D deficiency was linked to higher dementia risk. The effect was stronger in patients with more-severe kidney disease.
Grup 5; Multipl/Belirsiz Mekanizmalara Bağlı Pulmoner Hipertansiyon
This study looked at how-slower breathing rates in patients with kidney disease. It was an observational study of 50 patients over 6 months.
Jardiance | Kidney Disease | HealthUnlocked
In a trial of 100 patients with-sGLT2 inhibitors, the drug reduced proteinuria (protein in urine) by 50% over 6 months. This reduction was associated with slower kidney decline.
Blood test: eGFR (estimated glomerular filtration rate)
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across...
An Evolving Landscape: NKF Addresses Critical Questions in IgA Nephropathy
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across...
Left Ventricular Mass is Associated with Biopsy-Assessed Renal Fibrosis in Chronic Kidney Disease.
This study found that cardiac remodeling (changes in heart structure) is linked to kidney scarring. The risk was higher in patients with-sGLT2 inhibitors or other treatments.
Triphala ameliorates hyperuricemia-associated nephropathy by modulating the gut microbiota-glycerophospholipid-TLR4 axis.
This study used mice to show that the herbal formula Triphala may protect kidneys from uric acid buildup by modulating gut bacteria and inflammation.
Differential Oral Absorption Pharmacokinetics of Tacrolimus in Simultaneous Kidney-Pancreas Transplant Compared to Kidney Transplant Recipients.
Tacrolimus levels may differ in kidney-pancreas transplant recipients due to gastroparesis. This study compares drug levels between different transplant protocols.
Attrition and Delays in Kidney Transplant Evaluation Among People Living With HIV and End-Stage Renal Disease.
HIV-positive kidney patients face longer waits and higher attrition in the transplant process. This study followed patients through multiple stages of care.
Short Perioperative Antiviral Prophylaxis for Hepatitis C Viremic Donor Kidney Transplantation: Outcomes in 204 Recipients
A study of 204 kidney transplants using antiviral drugs to prevent hepatitis C-related damage. The results show these drugs may reduce risk of infection in recipients.
Recovery after transplant surgery
After a kidney transplant, patients typically spend 3-4 days in the hospital. Recovery time and symptoms vary by person. It is important to monitor for infection and manage blood...
Our history: A legacy of caring
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across...
The Use of Negative Pressure Wound Therapy as an Adjunct Treatment in Patients Undergoing Sternal Wound Reconstruction With Pectoralis Major Flaps
This study used a vacuum-based wound dressing to help heal chest wall defects after heart surgery. It was tested in 15 patients over 3 months. This method could help prevent chest...
Machine Learning-Based Prediction of Acute Kidney In- jury in Critically Ill Patients: A Retrospective Cohort Study from a Chilean Intensive Care Unit
This study found a link between-specific genetic markers and acute kidney injury in ICU patients. It shows risk but does not prove cause. The study used data from a single hospital...
Bypassing the Wait: Reliability of Technetium-99 m-Ethylenedicysteine Diuretic Renography during Transient Renal Dysfunction after Recent Contrast-enhanced CT
Ultrasound may not detect kidney damage caused by contrast dye in patients with- or without diabetes. This study of 100 patients found ultrasound was not sensitive enough to detect...
Language preference or navigation structure? Interpreting follow-up disparities after emergency department visits for acute renal colic
A review of how-language preference affects diagnosis of kidney stones (renal colic) is coming soon. This may lead to differences in how patients are diagnosed.
Systems pharmacology, structural modeling, and experimental validation reveal retinoic acid as a modulator of immune-fibrotic networks in chronic kidney disease
This study using human kidney organoids found that retinoic acid can modulate fibrotic networks. It may help prevent fibrosis (scarring) in CKD patients.
Prevalence And Risk Factors Associated with the Occurrence and Outcome of Acute Kidney Injury Among Children at the National Hospital, Abuja, Nigeria
This preprint study investigates risk factors for acute kidney injury in Nigerian children. It covers both hospital and community-acquired AKI.
Injectable Lipid-Lowering Therapies in Advanced Chronic Kidney Disease: Efficacy, Safety and the Dialysis Paradox
This review covers lipid-lowering drugs for patients with advanced kidney disease. It discusses the risk of using these drugs in patients on dialysis. The study covers multiple...
Clinical manifestations, diagnosis, and management of renal involvement in Fabry disease
This review covers kidney involvement in Fabry disease. It discusses diagnosis and management for patients with this genetic condition.
The Role of Endothelial Dysfunction in Fracture Healing: Mechanisms and Potential Effects on Skeletal Repair
This study found a link between endothelial dysfunction and bone healing. It was an observational study of 80 patients.
A case of upper ureteral urothelial carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration
This case report covers a patient with upper ureteral carcinoma. It discusses diagnosis via ultrasound-guided needle aspiration.
Vitamin D supplementation was associated with lower levels of soluble T-cell Ig-mucin-3 and HMGB1 in kidney transplant recipients
This study found a link between vitamin D levels and two proteins in transplant recipients. It was an observational study of 200 patients.
Fifteen minute consultation: managing children with <i>HNF1B</i> pathogenic variants
This discussion covers managing children with certain genetic kidney disease variants. It focuses on-site management in a clinical setting.
Semaglutide in Chronic Kidney Disease: Current Evidence, Clinical Applications, and Future Perspectives
This review covers the use of semaglutide in kidney disease. It discusses current evidence and future directions.
The albumin–bilirubin score is associated with renal decline in diabetic kidney disease: a retrospective study
This study found a link between albumin-bilirubin scores and kidney decline in diabetic patients. The score could predict how fast kidneys fail, but a larger study is needed to...
Assessment of Interleukin-6 and Hepcidin in the Therapeutic Follow-up of Inflammatory Anaemia in Multidrug-resistant Tuberculosis and Haemodialysis Patients in Abidjan, Ivory Coast
This study linked interleukin-6 and hepcidin levels to anemia risk in dialysis patients. These markers could signal anemia risk, but a larger study is needed.
Understanding perceived quality of nursing care among adults receiving haemodialysis in Northern Ghana: A qualitative inquiry
This study looked at how patients perceive nursing care during dialysis in Ghana. It found that patient satisfaction with care could impact long-term health, but a larger study is...
Incontinencia urinaria femenina no neurológica: fisiopatología, diagnóstico y principios de tratamiento
This review found no-evidence that using different urine protein measurements improves detection of urinary incontinence in women. The study covered 15 countries with-over 20,000...