← brief for 2026-08-15 · Slowing decline

Disease-driven post-transcriptional alterations and alternative splicing in podocytes in focal segmental glomerulosclerosis.

Key takeaways

This study uses zebrafish models to investigate how RNA splicing affects podocytes in FSGS. Results show molecular-level damage in kidney filtration cells.

Who did this work

Mattias F (Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.) · Tsoy O (Institute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.) · Iervolino A (Institute of Molecular Biology and Genetics (Biogem), Ariano Irpino, Italy.) · Simm S (Coburg University of Applied Sciences, Institute of Bioanalysis, Coburg, Germany.) · Hammer E (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.) · Gress A (Department of Drug Bioinformatics, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbrücken, Germany.) · Siegerist F (Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.) · Schindler M (Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.) · Lange T (Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.) · Ameling S (Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.) · Kacprowski T (Institute of Data Science in Biomedicine, Technische Universität Braunschweig, Braunschweig, Germany.) · List M (Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.)

Source

Paper · Europe PMC, CKD · 2026-08-13
https://doi.org/10.1038/s44321-026-00495-5