← brief for 2026-08-19 · Slowing decline

A population-scale transcriptional atlas of blood and tissue in lupus nephritis.

Article A Peer reviewed Meta-analysis or large trial

Key takeaways

This large study of 155 patients with lupus nephritis found that kidney scarring is driven by different immune cell types in each person. This means a one-size-fits-all approach to treating lupus nephritis may not work. The study used single-cell sequencing on kidney biopsies.

Who did this work

Sugiarto NW · Gurajala S · Curtis M · Eisenhaure TM · Arazi A · Fava A · Xiao Q · Mears J · Rovin B · Berthier CC · Zhao Y · Izmirly PM

Source

Article · PubMed, CKD progression and prevention · 2026 Aug 19
https://pubmed.ncbi.nlm.nih.gov/42616839/