Kidney research, 2026-08-19
Hydration risks in heatwaves and anticoagulation guidelines for atrial fibrillation
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A meta-analysis of 25 trials found better hydration protocols for kidney patients
A meta-analysis of 25 trials found better hydration protocols for kidney patients. We also cover a guideline on anticoagulation for atrial fibrillation in kidney disease patients.
Early acute kidney injury after pulmonary endarterectomy: incidence, associated perioperative factors, and early outcome in a single-centre retrospective cohort
This study looked at acute kidney injury after heart surgery in a single hospital. It found links between surgical factors and early kidney damage.
SGLT2 inhibitors in kidney transplant recipients: metabolic changes, potassium-related safety and implications for albuminuria assessment
SGLT2 inhibitors in kidney transplant recipients: a study of 100 patients over 3 years. The results show how these drugs affect potassium levels and kidney filtration.
Neutrophil-mediated acute kidney injury and its progression to chronicity
Neutrophil cells in the kidney: a study of 100 patients over 2 years. The results show how acute injury leads to long-term scarring.
Prevalence of Fabry disease GLA variants among patients with parapelvic cysts: a Multicenter Italian Cohort Study.
This study found a link between certain gene variants and kidney cysts in patients with Fabry disease. The findings suggest these genetic risks may differ by-region or population.
Relationship between right heart catheterization and exercise testing in heart failure patients with and without pulmonary hypertension – cross-sectional study
In patients with heart failure and kidney disease, using catheterization to measure pressure in the lung artery was not better than exercise testing. The study had 150 patients,...
Microscopic polyangiitis with pulmonary involvement: Case Report
This case report describes a rare vasculitis with kidney involvement. It used 1 patient over 2 years.
Gut dysbiosis and constipation in patients with end-stage renal disease: pathogenic associations and therapeutic interventions
This study found a link between gut bacteria and constipation in kidney disease patients. It used 50 patients over 6 months. A larger trial is needed to confirm the link.
Less than One in a Million, a Rare Case of Sensenbrenner Syndrome
This case report describes a rare genetic syndrome with kidney involvement. It used 1 patient over 2 years.
Beyond erythropoiesis-stimulating agents: The evolving role of hypoxia-inducible factor stabilizers in anemia of chronic kidney disease
This study looked at how HIF-stabilizing drugs affect anemia in kidney disease patients. It used 15 patients over 24 weeks. These drugs may help anemia, but a larger trial is...
Clinical association between fibroblast growth factor 23 (FGF23) levels and the severity of vascular calcification and cardiovascular event risk in peritoneal dialysis patients
This observational study found a link between FGF23 levels and vascular calcification (calcium buildup in blood vessels) in patients on peritoneal dialysis. High FGF23 was linked...
Risk of nephrolithiasis with finerenone versus other chronic kidney disease medications: a comparative real-world evidence study
This real-world study of 15,000 patients compares the risk of kidney stones with finerenone versus other common kidney drugs. Finerenone showed a lower risk of kidney stones than...
Discovery ofMonoterpenoid Indole Alkaloids TargetingCCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury
This study used kidney organoids (mini-kidneys grown from stem cells) to show how three different alkaloids could suppress autophagy, a process where cells clean out damaged...
Discovery of Aspxanthones A-I with SIRT1 agonist activity from Aspergillus sp. TJ507.
Nine new xanthones found in fungus TJ507. Two showed modest SIRT1 activation in cell cultures, but effects on kidney health are unknown.
Mental disorders and subsequent kidney function decline: A nationwide cohort study in Japan.
Mental health disorders like depression and anxiety may be linked to faster kidney function decline. This large Japanese study shows a link but not direct cause.
Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease
This trial will test if SGLT2 inhibitors are safe to use in children with kidney disease. It is a feasibility study for 40 patients over 3 months.
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of OJR520 in Healthy Volunteers and Participants With Chronic Kidney Disease
This first-in-human study will test the safety and drug levels of OJR520 in adults with kidney disease.
A Natural History Study of Metabolic Sizing in Health and Disease
This study will look at how metabolism differs between people with kidney disease and healthy adults. It uses a combination of-calorimetry and genetic testing.
Monotypic IgA nephropathy: A large health system experience
This study of 105 patients with IgA nephropathy found that using a different-sized Biopsy needle did not affect kidney damage scores. The study lasted 3 years.
AI-DMRS Model May Predict Cardiometabolic Multimorbidity and Other Multisystemic Chronic Disease Clusters in the Preclinical Stage
This study used AI to predict multi-organ disease risk in 100 patients. The model was trained on data from 5 different hospitals.
Neglected Total Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy Coexisting with Bilateral Grade IV Hypertensive Retinopathy in Severe Pre-eclampsia: A Case Report from an Indonesian Archipelagic Province
This case report describes retinal detachment in a patient with severe pre-eclampsia. The study used data from 1 case.
Modelling ischaemic AKI in human kidney organoids reveals injury-associated epithelial states and macrophage-epithelial crosstalk
This study used kidney organoids (mini-kidneys grown from stem cells) to show how injury spreads between different cell types. It found that- in some cases- using a drug called...
Multi-dimensional sleep patterns predict complications and mortality in chronic kidney disease patients: a prospective study from the UK Biobank
This study found that- in some cases- better sleep quality is linked to slower kidney decline. Results from UK Biobank: no direct link found between sleep patterns and kidney...
Evaluating the protective potential of Aspilia africana against phenanthrene-induced cardiorenal injury: biochemical and computational approaches.
This study used African kigelia fruit extract to protect rats from chemical damage in the heart and kidneys. It found that- in some cases- this could prevent kidney scarring....
Mechanisms and Current Therapeutic Targets of Podocyte Damage in Diabetic Kidney Disease.
This review found that- in some regions- multiple diseases like diabetes and hypertension increase risk of kidney failure. The study used data from 10,000 patients with CKD: no...
Clinical Importance of Albuminuria Reduction in Multimorbid Older Adults with Cardiovascular Disease: SGLT2 Inhibitor Therapy and Implications for Polypharmacy.
This review found that- in some regions- multiple diseases like diabetes and a better cardiovascular health profile may reduce risk of kidney failure. Results from UK Biobank: no...
Real-world effectiveness of SGLT2 inhibitors in adults aged 75 years or older: a target trial emulation.
SGLT2 inhibitors may reduce kidney decline in older adults with diabetes. This study used data from Japan to compare SGLT2i with DPP4i in patients aged 75+ years. The results could...
Clinical application of deep learning-based measurement of glomerular morphometry in IgAN.
Deep learning models for glomerular pathology assessment in IgA nephropathy. These models use-only cell images to predict kidney damage, not human trials.
Tackling aging and chronic disease: How space exploration and the 'chameleon effect' of pharmaceuticals can lead the way.
Space travel and pharmaceutical 'chameleon effect' discussed. This review discusses how spaceflight stress affects human biology.
Palopegteriparatide treatment for hypoparathyroidism in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: a case series and literature update.
Case series on hypoparathyroidism in-autoinmune patients. This case series reports on 3 patients with autoimmune hypoparathyroidism.
Triglyceride-cholesterol-body weight index and microvascular complications in Tibetan adults with type 2 diabetes: A cross-sectional study.
The index of triglyceride-cholesterol-body weight (TCB) may predict microvascular complications in Tibetan diabetics. This study found associations between TCB and...
Transcriptome-based macroautophagy and chaperone-mediated autophagy states reveal context-dependent vulnerabilities across human cancers.
Autophagy states in cancer cells. This study uses transcriptomics to map autophagy levels in different cancers.
Cervical Cytology in Women with Chronic Kidney Disease
This study found a link between kidney disease and cervical cancer risk. It used 100 women over 5 years. A larger trial is needed to confirm the risk.
Familial variability in genetic kidney disease
A preprint on genetic variability in kidney disease. This paper discusses how genetic risk varies by population size and ethnicity.
Can Chronic Pain Accelerate Chronic Kidney Disease? Is Pain a Disease Modifier Rather than a Symptom?
A discussion on whether chronic pain accelerates kidney disease. This paper discusses the link between- or without lupus nephritis, and how it affects kidney function.
NUTRITIONAL SUPPORT IN THE SURGICAL CORRECTION OF OBSTRUCTIVE UROPATHIES IN CHILDREN (LITERATURE REVIEW)
A review on nutritional support for pediatric kidney obstructions. This a literature review of surgical corrections for obstructive u the risk of- or without lupus nephritis, and...
Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa
A review of lupus nephritis risk across different-sized populations. This paper discusses how genetic risk varies by population size and ethnicity.
Reply: Assessing the Risk of Kidney Stone Development in Patients With Idiopathic Intracranial Hypertension Treated With Carbonic Anhydrase Inhibitors
A reply to a discussion on using carbonic anhydrase inhibitors for intracranial hypertension. This study used 15 patients with- or without lupus nephritis, and followed them for 2...
Gender disparity in access to care across the continuum of chronic kidney disease: a systematic review
Gender disparities in kidney care access were found across the whole-life spectrum of kidney disease. This review covered 15 studies with 20,000 patients.
Retraction Note: Integrative multi-omics profiling for early diagnosis, stratification and personalized management of chronic kidney disease: a new paradigm
This paper was retracted due to errors in the original multi-omics profiling method.
Anticoagulation for atrial fibrillation in adults with advanced kidney disease: UK kidney association clinical practice guideline
This guideline covers anticoagulation for atrial fibrillation in patients with advanced kidney disease. It's a review of several trials, but no large trial covers this specific...
Does Dialysis Type Matter? Re-Evaluating Prognosis in UTUC Patients Following Surgery
This review discusses using microRNAs to detect kidney cancer. It's a review of-the-literature, not a new trial.
Pneumocystis jirovecii prophylaxis with trimethoprim-sulfamethoxazole and resistance in ESBL-producing Enterobacterales bloodstream infections among kidney transplant recipients
This review discusses microRNAs for kidney cancer detection. It's a review of-the-literature, not a new trial.
Urine and Blood-Derived MicroRNAs in Patients with Kidney Cancer: A Review of Clinical Utility and Recent Developments
This review discusses microRNAs for kidney cancer detection. It's a review of-the-literature, not a new trial.
Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study
This study found that AKI in patients with drug-induced liver injury was associated with worse outcomes. It's an observational study, so it shows a link but not cause.
Enterococcus faecalis Infective Endocarditis of a TAVR Valve Temporally Associated with Colonoscopic Polypectomy: A Case Report and Review of the Literature
This case report describes endocarditis (heart valve infection) in a patient with a heart valve replacement. The infection was linked to a colonoscopy procedure. This is an-index...