← brief for 2026-08-19 · Slowing decline

Discovery ofMonoterpenoid Indole Alkaloids TargetingCCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury

Paper D Peer reviewed Preclinical

Key takeaways

This study used kidney organoids (mini-kidneys grown from stem cells) to show how three different alkaloids could suppress autophagy, a process where cells clean out damaged components. This was done in organoids, not people.

Who did this work

Xue Qiao (Wuhan University) · Chen Shun-qing (Wuhan University) · Ariel M. Sarotti (National University of Rosario) · Jixian Zhang (University of Jinan) · Yu-Ting Zhong (Wuhan University) · Wei-Chen Chen (Wuhan University) · Xiaofen Wang (Wuhan University) · Wumei Wang (Tibet University) · Jianying Huang (Wuhan University) · Xiao-Yan Wu (Wuhan University) · Hui‐Ming Wang (Wuhan University) · Shugeng Cao (University of Hawaii at Hilo)

Source

Paper · OpenAlex, CKD works · 2026-08-18
https://doi.org/10.1021/acs.jmedchem.6c02215