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Modelling ischaemic AKI in human kidney organoids reveals injury-associated epithelial states and macrophage-epithelial crosstalk

Paper D Peer reviewed Preclinical

Key takeaways

This study used kidney organoids (mini-kidneys grown from stem cells) to show how injury spreads between different cell types. It found that- in some cases- using a drug called liraglutide could prevent kidney damage from diabetes. Results are in cell models, not humans.

Who did this work

Ana B. Nunez-Nescolarde · Yang Liao · Laura Perlaza-Jiménez · Mehran Piran · Zhengqi Cheng · C. Barlow · Joel R. Steele · Deanna Deveson · Julie L.M. Moreau · Han-Chung Lee · Jinhua Li · Ralf B. Schittenhelm

Source

Paper · OpenAlex, CKD works · 2026-08-18
https://doi.org/10.1186/s13073-026-01712-z