← brief for 2026-08-26 · Transplant & xeno

Anti-PAR2 autoantibodies are associated with chronic histological injury in kidney transplant recipients

Paper C Peer reviewed Observational

Key takeaways

Researchers found that kidney transplant patients carrying a certain self-attacking antibody, called anti-PAR2, were more likely to show long term damage in kidney biopsy samples. This shows a link between the antibody and the damage. It does not prove the antibody caused it, since sicker kidneys could also drive antibody production. If it holds up, it could become a blood test that flags transplants at risk.

Who did this work

Karolina Marek-Bukowiec (Wroclaw Medical University) · Jakub Mizera (Wroclaw Medical University) · Harald Heidecke (Cell Medica (Switzerland)) · Kai Schulze‐Forster (Cell Medica (Switzerland)) · Łucja Janek (Wroclaw Medical University) · Ignacy Tarski (Department of Embryology) · Mateusz Minor (Wroclaw Medical University) · Guido Moll (Humboldt-Universität zu Berlin) · Rusan Catar (Humboldt-Universität zu Berlin) · Patryk Jerzak (Wroclaw Medical University) · Magdalena Kuriata-Kordek (Wroclaw Medical University) · Piotr Donizy (Wroclaw Medical University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-20
https://doi.org/10.3389/fimmu.2026.1923916