Kidney research, 2026-08-26
A new review confirms SGLT2 inhibitors help older adults with heart failure, and a stent choice affects transplant recovery
Today’s findings focus on two strong, practice-relevant topics: SGLT2 inhibitors for heart and kidney protection in older adults, and stent choice after transplant surgery. A smaller trial looked at curcumin versus pentoxifylline, but its size and design limit how much weight to give it. Most other studies were observational or background work, showing links without proving cause-and-effect.
GLP-1 receptor agonists are associated with lower kidney cancer risk after metabolic bariatric surgery.
People who took GLP-1 drugs after weight-loss surgery had lower kidney cancer risk than those on other diabetes medicines, but this study only shows a link — it cannot prove the...
The Congenital Heart Disease in Children: Kidney-Associated Conditions with Epidemiologic Endpoints (CHICKADEE) study: Study design and protocol
This paper lays out the plan for a study called CHICKADEE. It will follow children born with heart defects to see how often kidney problems show up and how far they progress. The...
Clinical and genetic spectrum of distal renal tubular acidosis in children: findings from Indian tubular disorders registry
Doctors in India pulled together registry records of children with distal renal tubular acidosis, a condition where the kidneys cannot clear acid from the blood properly. The...
Challenges of Biomarker Application in Patients with Cardiorenal Syndrome
A review of the blood and urine tests doctors use when heart failure and kidney disease happen at the same time, a pairing called cardiorenal syndrome. The authors argue these...
Is this the end of the beta-blocker debate in hemodialysis? — NephJC
This is a journal club discussion, not a new study. Doctors are arguing about beta blockers, a common blood pressure and heart drug, for people on dialysis. Two things drive the...
Creatine supplementation and the young kidney
This review of existing studies found that creatine supplements do not seem to harm healthy kidneys, but people under age 30 with low kidney filtering rate (eGFR), past kidney...
Anrikefon vs Nalfurafine for Sleep Quality in Hemodialysis Patients With CKD-aP
A new trial will compare an experimental IV drug (Anruikefen) to the standard oral medicine (nalfurafine) for sleep problems caused by itchy skin in hemodialysis patients. There...
A Study to Evaluate Safety, Tolerability and Efficacy of AP306 at Fixed Doses in Dialysis Participants With Hyperphosphatemia
This trial will test how safe and well-tolerated a drug called AP306 is at fixed doses in people on dialysis who have high phosphate levels. There are no results yet—this is a...
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
A large Phase III trial will test if adding Baxdrostat to the diabetes drug dapagliflozin helps protect kidneys and lowers heart death risk in people with chronic kidney disease...
Five-Year Cardiorenal Outcomes and Longitudinal Chronic Kidney Disease Screening in People with Type 2 Diabetes Managed by Endocrinologists: A Nationwide Retrospective Cohort Study.
This nationwide study of people with type 2 diabetes found that those who saw an endocrinologist had better long-term heart and kidney outcomes, but only about half got regular...
Exploratory Mediation-Informed Analysis and Dose-Response Analysis of Uric Acid Reduction and Kidney Outcomes in SGLT2 Inhibitor Therapy Compared to Allopurinol.
A retrospective study of diabetics with high uric acid found that those taking SGLT2 inhibitors had lower uric acid and better kidney outcomes than those on allopurinol, but...
Efficacy of Yishen Jiangzhuo granules in the treatment of chronic kidney disease stages 3-4: a retrospective cohort study.
This study looked back at 1,247 people with stage 3–4 kidney disease and found those who took Yishen Jiangzhuo granules for over 6 months had slower kidney decline, but because it...
Glucagon-Like Peptide 1 Receptor Agonists, Mortality, and Cardiovascular Outcomes in Serious Mental Illness.
A review of 1.2 million adults with serious mental illness found those who took GLP-1 drugs had about a 20% lower risk of death or major heart problems over two years compared to...
Empagliflozin Improves Post-Infarct Heart Failure Through Fibroblast Growth Factor-21 and Ketone Body Oxidation Pathway.
In mice that had heart attacks, empagliflozin improved heart function by changing how the body uses fat and ketones—this effect depended on two proteins, but no people were...
Prescription of SGLT-2 inhibitors alone or in combination with RAS-inhibitors in patients with diabetes mellitus and comorbid cardiovascular disease, chronic kidney disease or cardiorenal disease: a real-world evidence study from the REPOSI registry.
This real-world study followed 1372 older adults with diabetes and heart or kidney disease to see how SGLT-2 inhibitors, alone or with other blood pressure drugs, affected their...
Colquhounia Root Tablet as an immune-metabolic adjunct for residual kidney risk in heavy-proteinuric type 2 diabetic kidney disease: a propensity-score-matched real-world study.
This study compared 128 people with heavy protein in their urine and type 2 kidney disease who took Colquhounia Root Tablet with a similar group who did not. Those taking the...
Targeting Runx1 Slows Cyst Growth in Autosomal Dominant Polycystic Kidney Disease
Blocking a protein called Runx1 slowed the growth of kidney cysts in polycystic kidney disease, an inherited condition where fluid-filled sacs crowd out working kidney tissue. This...
Imaging-Defined Renal Ectopic Fat Related to Blood Pressure and Hypertension Phenotypes in Adults: A Scoping Review Protocol
This is a plan for a future review, not the review itself. Researchers intend to gather studies on fat seen around and inside the kidneys on scans, and whether it tracks with high...
Hypertension, not low-density lipoprotein cholesterol: what a polygenic lens reveals about chronic kidney disease risk
This is a commentary on genetics research suggesting that inherited risk for high blood pressure raises the chance of chronic kidney disease, while inherited risk for LDL...
Dialysis Discontinuation Rates at Low Levels of Kidney Function in Patients with Acute Kidney Injury on Intermittent Hemodialysis
This study looked at people whose kidneys suddenly failed and who were put on dialysis, and asked at what level of leftover kidney function they were able to stop dialysis. Some...
IgA1 hinge-region O-glycoform signatures associated with disease phase and kidney involvement in pediatric IgA vasculitis: a cross-sectional mass-spectrometry study
Children with IgA vasculitis, a blood vessel disease that can attack the kidneys, had unusual sugar patterns on an antibody called IgA1. Researchers built a lab test to measure...
Heterozygous truncating variants in BICC1 are a novel cause of autosomal-dominant tubulointerstitial kidney disease
Some families pass down a slow kidney disease that usually leads to kidney failure around age 45, with no protein in the urine and few other warning signs. Researchers found broken...
Endothelin Receptor Antagonists in Resistant Hypertension and Proteinuric Kidney Disease: Receptor Strategy and Volume Management.
This is a review article about endothelin receptor blockers, a class of blood pressure drug that also lowers protein in the urine. The authors walk through which drug, which dose,...
Huangkui Capsule Effects in IgAN Through TLR4-Mediated Inflammatory Signaling.
Huangkui capsule is a Chinese herbal medicine made from a hibiscus plant and already used for kidney disease. Researchers gave it to rats with IgA nephropathy, the most common...
Review: Posterior urethral valves (PUV) … what do we know?
Posterior urethral valves are a birth defect that blocks the flow of urine in boys. It is a leading cause of kidney failure in children. This review mapped the research on how...
Sex differences in trajectories to cardio-renal and mental health outcomes following the onset of type 2 diabetes: An observational cohort study using multi-state analysis in the UK Clinical Practice Research Datalink.
This study followed UK adults through their health records after they were diagnosed with type 2 diabetes. It tracked who later developed heart disease, kidney failure, depression...
Does Intravenous Iron Improve Survival and Physical Function and Reduce Heart Failure Events in Patients with Chronic Kidney Disease?
Low iron is common in kidney disease, but current guidelines only give iron when a person is also anemic, meaning low in red blood cells. This article argues that iron given...
Traditional Chinese Medicine related factors of planned dialysis in chronic kidney disease stage 5 patients with type 2 diabetes mellitus: a multicenter cross-sectional study.
This study across several Chinese hospitals described people with stage 5 kidney disease, the most advanced stage, who also have type 2 diabetes. It recorded their symptoms using...
Association of HDL2b with chronic kidney disease in type 2 diabetes mellitus populations.
HDL is often called good cholesterol and has long been assumed to protect the kidneys. This study measured different subtypes of HDL in Chinese adults with type 2 diabetes and...
Berberrubine alleviates PCS-induced tubular injury via HNRNPF/NR4A1/ER stress axis.
Berberrubine is what the body makes from berberine, a plant compound, and it is absorbed better than berberine itself. Researchers tested it against p cresyl sulfate, a waste toxin...
Diagnostic Performance of Reticulocyte Hemoglobin Content (CHr) for Iron Deficiency in Chronic Kidney Disease: A Reanalysis of a Published South African Dataset.
A reanalysis of 399 South African patients found that measuring iron in new red blood cells (called CHr) worked better than the usual ferritin test to spot true iron deficiency in...
Association of Microalbuminuria, Protein-Creatinine Ratio, and Derived Renal Risk Indices in Patients With Type 2 Diabetes Mellitus in a South Indian Population: A Cross-Sectional Study.
In 204 South Indian adults with type 2 diabetes, higher protein in the urine and certain lab ratios were linked to worse kidney health — but this study cannot prove those things...
Association of routine laboratory parameters with chronic kidney disease-mineral and bone disorder in patients on maintenance hemodialysis: A retrospective study.
In 156 adults on dialysis, routine blood tests like calcium and phosphate levels were linked to bone and mineral problems — but this retrospective study shows only an association,...
Thyroid tests in kidney failure: diagnostic stewardship before levothyroxine therapy.
This review explains how kidney failure can make thyroid blood tests look abnormal without actual thyroid disease — and why doctors should be careful before starting lifelong...
Effect of Contrast-Enhanced CT Brain on Renal Function in Potential Intraarterial Therapy Patients in the Emergency Department.
In 112 emergency room stroke patients who got a CT scan with contrast dye, kidney filtering rate dropped slightly on average — but this observational study cannot prove the dye...
Efficacy and safety of finerenone in adults with IgA nephropathy: a 12-month real-world study.
Among 142 adults with IgA nephropathy, the drug finerenone lowered protein in the urine by about 35% and slowed kidney filtering rate decline over 12 months — but this small...
Merging artificial intelligence and retinal vascular geometric parameters: A novel tool for diagnosis and prognosis prediction of diabetic nephropathy.
Scientists built a tool using eye scans and health data to predict diabetic kidney disease, but this study only shows a link — it did not prove the tool can reliably diagnose or...
Advances in the Treatment of Diabetic Kidney Disease With Traditional Chinese Medicine.
This article reviews how traditional Chinese medicine might help diabetic kidney disease, but it does not report any new results — only summarizes past lab and animal studies.
Pharmacokinetics, Elimination and Dialyzability of HRS-9231 in Patients with Varying Degrees of Renal Impairment.
A new dye used in imaging tests was studied in 40 people with kidney disease, including those on dialysis — the study found how quickly the body removes it, which helps doctors...
Combined Assessment of Estimated Glomerular Filtration Rate and Albuminuria Among Apparently Healthy Young Adults: A Cross-Sectional Study
This study measured two kidney tests at once in healthy young adults: the kidney filtering rate (eGFR) and protein leaking into the urine (albuminuria). It is a snapshot of one...
The pathological mechanisms and potential therapeutic strategies for renal anemia
This is a review article about anemia in kidney disease, meaning low red blood cell counts that leave people pale, cold and exhausted. It walks through why failing kidneys cause...
Exploring the Relationship of Serum Albumin With Different Stages of Chronic Kidney Disease: A Cross Sectional Study in a Tertiary Care Hospital
This hospital study looked at whether blood levels of albumin, the main protein in blood, drop as chronic kidney disease gets worse. It measured everyone at a single point in time...
Finerenone in type 1 diabetes and chronic kidney disease
This is a discussion piece about using finerenone, a drug that blocks a hormone signal that scars and inflames the kidney, in people who have type 1 diabetes along with kidney...
Case Report: A case of acute kidney injury due to star fruit-infused liquor
This is a single case report: one person developed sudden kidney injury after drinking liquor infused with star fruit. Star fruit contains a toxin that damaged kidneys cannot...
Liver iron concentration and renal dysfunction in β-thalassemia: a case series and exploratory clinical observations
This is a small case series describing kidney problems in people with beta-thalassemia, an inherited blood disorder that requires repeated transfusions and leaves excess iron in...
Translational advances in diabetic nephropathy management: integrating nanoformulation-based drug delivery systems
This is a review of tiny particle drug carriers, called nanoformulations, for kidney damage caused by diabetes. The idea is to pack a drug inside a very small carrier so more of it...
Plasma Levels of Growth Differentiation Factor 15 and Adverse Kidney Outcomes
Researchers measured a blood protein called GDF-15, a signal the body makes when cells are under stress, and then tracked how people's kidneys did over time. Higher levels went...
Adaptive immune cells and kidney function in older adults: sex-specific associations in the health and retirement study (HRS)
Researchers looked at immune cells in the blood and kidney filtering rate (eGFR) in older adults taking part in a large US study on aging. Certain immune cell patterns tracked with...
Recent advances in PANoptosis research in kidney disease: mechanistic networks, pathological roles, and potential intervention strategies
A review of PANoptosis, a form of cell death that mixes together several ways a cell can die, in kidney disease. It gathers lab findings on how these cell death pathways may drive...
Integrative transcriptomic and single-cell analysis identifies anoikis-related molecular signatures in vascular calcification
Researchers sifted gene activity data, including readings from single cells, to find molecular patterns in blood vessels that have hardened with calcium. That hardening is common...
Twist Family BHLH Transcription Factor 1 orchestrates hypoxia-lactate crosstalk to bridge glycolytic flux and tubular maladaptation in fibrotic kidneys
In test tubes and animals, a protein called Twist1 was found to help link low oxygen and sugar use in kidney cells during scarring, but this work has not been tested in people yet....
Angiotensin receptor blocker ameliorates the development of tubulointerstitial injury and fibrosis associated with tubular proteinuria observed in subclinical diabetic kidney disease
This study tested a blood pressure drug called an angiotensin receptor blocker, or ARB, in early diabetic kidney disease. The drug reduced damage and scarring in the kidney's...
The MUSCLE-GLP1-CKD study: design and rationale of a prospective real-world cohort evaluating muscle health after subcutaneous semaglutide initiation in chronic kidney disease and type 2 diabetes
This paper describes the plan for a study, not its findings. Researchers will follow people who have both chronic kidney disease and type 2 diabetes after they start semaglutide, a...
Kidney disease progression during and after pregnancy in a Col4a3-/- mouse model of Alport syndrome: an experimental study
This study looked at whether pregnancy speeds up kidney damage in Alport syndrome, an inherited disease that attacks the kidney's filters. It was done in mice bred to carry the...
Association Between Postoperative Platelet-to-Hemoglobin Ratio Trajectories and Acute Kidney Injury in Patients Undergoing Cardiac Surgery: A Retrospective Cohort Study with External Validation
This study looked back at patients who had heart surgery and tracked how their platelet count compared with their hemoglobin over the following days. Certain patterns in that ratio...
Uric acid in cardiovascular and renal disease: Marker, mediator, or therapeutic target?
This is a review article, not a new study. It asks whether uric acid, a waste product that builds up in blood, simply signals heart and kidney trouble or actually causes it. The...
Safety & efficacy of sodium glucose co-transport 2 (SGLT2) inhibitors in elderly patients with heart failure
SGLT2 inhibitors are pills first made for diabetes that also protect the heart and kidneys. This review pooled trial data on older adults with heart failure and found they cut...
Heart-type fatty acid-binding protein as a potential biomarker for hypertension in pediatric chronic kidney disease
Children with chronic kidney disease often develop high blood pressure, which speeds kidney damage. This study measured a blood protein called H-FABP, released when heart muscle is...
How to treat „FSGS“? A conceptual framework
FSGS is a pattern of scarring in the kidney's filters that has many different underlying causes. This opinion piece argues doctors should stop treating it as one disease and...
Longitudinal bone loss in patients with stage 3 CKD: a study based on densitometry and HR-pQCT
People with stage 3 kidney disease, meaning moderately reduced filtering, were followed over time with two kinds of bone scans. Their bone density dropped faster than expected, and...
PALADIN—intravenous iron strategies for the management of anaemia in adults receiving peritoneal dialysis: rationale and design of a randomised controlled feasibility trial
PALADIN is a randomized trial that is just starting, and this paper only describes its design. It will compare ways of giving iron through a vein to treat anemia, or low red blood...
Vascular Dysfunction in Renal Injury and Cognitive Dysfunction: The Central Role of Endothelin-1
This is a review of lab and animal work on endothelin-1, a natural substance that makes blood vessels tighten. The authors argue it is a shared driver of both kidney damage and...
Acute kidney injury, baseline renal function, troponin, and survival after myocardial infarction
In people who had a heart attack, this study looked at whether sudden kidney injury, starting kidney function, and troponin, a blood marker of heart damage, predicted who survived....
Factors associated with disease severity in adults with acute glomerulonephritis: a descriptive retrospective cohort study
This study looked back at adults hospitalized with acute glomerulonephritis, a sudden inflammation of the kidney's filters, to find what made some cases more severe. It identified...
Integrated Adverse Outcome Pathway and Machine Learning Reveal the Mode of Action and Biomarkers of Lithium-Induced Risk of Chronic Kidney Disease
Lithium, a long-used mood-stabilizing drug, is known to damage kidneys over years. This work combined lab pathway modeling with machine learning to map how that damage happens and...
Evidence-based guidelines for the diagnosis and management of adult-onset IgA vasculitis
Doctors published new guidelines for adult-onset IgA vasculitis, an immune illness that inflames small blood vessels and often damages the kidneys. The guidelines gather existing...
Fatal intoxication caused by conventional-dose methotrexate in an elderly patient with end-stage renal disease: A cautionary case report.
A 71-year-old man with rheumatoid arthritis and failing kidneys died after taking a normal low dose of methotrexate, a common arthritis drug. Healthy kidneys clear this drug from...
Impact of Menopause and Menopausal Hormone Therapy on Liver-Kidney-Metabolic Health.
This review looks at how menopause changes the way the body handles sugar and fat, and how those changes may affect the liver and kidneys. It argues that fatty liver disease drives...
FDA label: 1 INDICATIONS AND USAGE INPEFA is indicated to reduce the ri
The FDA label for INPEFA (sotagliflozin) covers adults with heart failure, or with type 2 diabetes plus chronic kidney disease and other heart risk factors. The drug is a type of...
Improving the Histologic Classification of Advanced Diabetic Nephropathy Based on the Transformative Research in Diabetic Nephropathy (TRIDENT) Findings
Diabetic kidney disease is the top cause of kidney failure worldwide, and doctors judge how bad it is by looking at a small piece of kidney tissue under a microscope. The scoring...
Outcomes from the International Society of Nephrology Forum on Complement Therapeutics in C3G & IgAN
Kidney specialists met to review drugs that block complement, a part of the immune system that can attack the kidney's filters. In C3 glomerulopathy and a related filter disease,...
From podocyte biology to glomerular medicine: The 15th International Podocyte Conference 2025
This is a recap of the 15th International Podocyte Conference, held in Hamburg from June 10 to 13, 2025. Podocytes are the delicate cells that form the kidney's filter, and damage...
A podocyte-specific damage score to enable mapping of disease progression
This short journal piece describes a new score that measures damage to podocytes, the cells that build the kidney's filter. The goal is to map how far a person's kidney disease has...
PharmaPlain: SOUL trial looking at the effect of oral semaglutide on cardiovascular outcomes in people with type 2 diabetes and atherosclerotic cardiovascular disease and/or chronic kidney disease.
This is a short plain-language explainer about the SOUL trial, not the trial results themselves. SOUL tested semaglutide taken as a pill in people with type 2 diabetes who also had...
Early combination therapy in type 2 diabetes: Rethinking initial treatment strategies.
This is an opinion and review article about how doctors start treatment for type 2 diabetes. The usual approach begins with one drug, metformin, and adds more only after blood...
Glucagon-Like Peptide-1 Receptor Agonist Use and Risks of Hospitalization and Mortality in Patients with End-Stage Kidney Disease.
Researchers looked at records of people who had just reached kidney failure and needed dialysis, comparing those taking GLP-1 drugs like semaglutide with those who were not. The...
Metabolic Syndrome: From Mechanisms to Therapeutic Interventions.
A broad review of metabolic syndrome, the cluster of problems that includes extra weight around the middle, high blood sugar, high blood pressure, and bad cholesterol. The authors...
Emerging therapies for diabetic kidney disease: beyond SGLT2 inhibitors.
A review of the next wave of drugs for kidney disease caused by diabetes, looking past the two treatments already in wide use: blood pressure drugs that act on the...
Targeting Inflammation in Chronic Kidney Disease: Pathophysiological Insights and Emerging Therapeutic Strategies
A review of inflammation as a driver of chronic kidney disease, meaning the slow, low-level immune activity that scars kidney tissue over years. The authors describe the biology...
The Connection Between Blood Pressure, Kidneys, and Heart Health
A short video explaining how high blood pressure and kidney disease make each other worse. High pressure damages the tiny filters in the kidneys, and damaged kidneys push blood...
Association of semaglutide use with kidney outcomes in adults with ADPKD: A propensity score-matched real-world study.
Researchers looked back through a large database of health records for adults with polycystic kidney disease, an inherited condition that fills the kidneys with fluid sacs and...
Chronic Kidney Disease with Sjögren's Syndrome and Hyperthyroidism: Discrepant Creatinine- and Cystatin C-Based eGFR.
A 70-year-old woman had kidney disease, an overactive thyroid, and Sjogren's syndrome, an immune condition that dries out the eyes and mouth. Her two blood tests for kidney...
The Role of Bariatric Surgery in Kidney Disease: Evidence, Controversies, and Future Needs.
This is a review article about weight loss surgery for people with kidney disease. It explains how extra body fat harms kidneys: it drives insulin resistance, high blood pressure,...
Enhancing Physical Function in Older Adults With Chronic Kidney Disease
A pilot trial will test if a 12-week high-velocity resistance training program is safe and feasible for older adults with stage 4 or 5 kidney disease. Researchers will compare it...
Broccoli Sprout Extract for Glycemic Management in Patients with Chronic Kidney Disease and Type 2 Diabetes: A Randomized Double-Blind Placebo-Controlled Trial.
In a small trial of 120 people with type 2 diabetes and stage 3b–4 kidney disease, those who took broccoli sprout extract for 12 weeks had blood sugar levels drop about 0.8% on...
How effective is Rhodiola rosea for stage 3 chronic kidney disease (CKD)?
This asks whether the herb Rhodiola rosea helps people with stage 3 chronic kidney disease. It is a question-and-answer write-up, not a study, and it reports no trial and no...
Associations of sedentary behavior and physical activity with serum uric acid in middle-aged and older adults with and without chronic kidney disease.
Researchers measured activity and blood uric acid in 294 adults aged 45 to 85, some with chronic kidney disease and some without. Uric acid is a waste product that builds up when...
The impact of new obesity definitions on prevalence and health outcomes.
Using new obesity definitions in over 400,000 UK adults changed how many people were labeled obese and linked those labels to higher risks of diabetes and heart disease — but this...
How effective are herbal supplements in managing stages 2 to 4 chronic kidney disease?
This asks how well herbal supplements work for stage 2 to 4 chronic kidney disease. It is posted on Zenodo, an open repository that does not peer review what it hosts, so it has...
Which supplements are beneficial for patients with mild to moderate chronic kidney disease (CKD)?
This is a short write-up asking which supplements help people with mild to moderate kidney disease. It was posted to an open file archive, not published in a journal that checks...
Lifestyle Intervention and Its Effects on Inflammatory Cytokines and Oxidative Stress Markers in Diabetic Chronic Kidney Disease Patients: A Randomized Controlled Trial
A randomized trial tested a lifestyle program in people who have both diabetes and kidney disease. It measured inflammation markers and oxidative stress markers, which are blood...
Association of low calf circumference and underweight with sarcopenia in older adults with chronic kidney disease: a cross-sectional study
In older adults with chronic kidney disease, thinner calves and low body weight went along with sarcopenia, which is serious loss of muscle and strength. This was a snapshot study,...
A randomized controlled trial evaluating the impact of curcumin versus pentoxifylline on patients with chronic kidney disease
This was a randomized trial comparing curcumin, the yellow compound in turmeric, with pentoxifylline, a drug that improves blood flow, in people with chronic kidney disease. Both...
Lifestyle Changes as a Strategy for Prevention and Control of Chronic Noncommunicable Diseases and Conditions such as Chronic Kidney Disease
This is a general discussion piece about using diet, exercise, and other daily habits to prevent long-term diseases, including chronic kidney disease. It summarizes existing advice...
Bioelectrical impedance analysis versus dual-energy X-ray absorptiometry for body composition assessment in children with chronic kidney disease
Children with kidney disease need their muscle and fat measured accurately, because fluid buildup makes weight alone misleading. This study compared a quick, cheap method using a...
Dietary nitrate supplementation in CKD pregnancy — NephJC
A kidney journal club is discussing dietary nitrate, the compound in beetroot juice, for pregnant women with chronic kidney disease. Pregnancy is risky here: in stages 3 to 5,...
Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients
This trial is starting to test if combining medicine with cognitive behavioral therapy (CBT) helps dialysis patients with pain, fatigue, or depression. There are no results...
The effectiveness of nature-based interventions on mental health: A systematic review.
A large review of many studies found that spending time in nature — like walking in a park or gardening — lowered anxiety and depression symptoms, even in people with long-term...
Effectiveness of Acupuncture Combined with Nursing in Children with Nondialysis Chronic Kidney Disease: A Retrospective Study
This study looked back at records of children with chronic kidney disease who were not on dialysis and compared those who got acupuncture plus nursing care with those who got...
Feasibility of heart rate monitoring in hemodialysis patients using visible imaging: a pilot study
Researchers tested whether an ordinary video camera can read heart rate in people during dialysis, with nothing touching the skin. This was a pilot, a small first test of whether...
Remodeling lipid and mitochondrial homeostasis: a novel mechanism by which polydatin attenuates renal tubular senescence in chronic kidney disease.
In test tubes and mice, polydatin—a compound from Japanese knotweed—reduced signs of aging in kidney cells by fixing lipid and mitochondrial problems, but no people have been...
Dual roles of renal tubular mitochondrial Akt1 in protecting against diabetic nephropathy and improving body glucose metabolism.
Scientists engineered mice with a special version of the Akt1 protein in kidney tubules and found it protected against diabetic kidney damage and improved blood sugar, but this...
MANF clears mutant uromodulin in human kidney organoids of autosomal dominant tubulointerstitial kidney disease.
In lab-grown human kidney organoids from patients with a rare inherited disease, a protein called MANF cleared mutant uromodulin and reduced cell stress, but this has not been...
Evaluating EndoC βH5 pseudoislets as a model for human islet transplantation.
Scientists transplanted lab-made insulin-secreting cell clusters into mice and saw they survived for 4 weeks and released insulin when blood sugar rose, but this is early work—no...
Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A
A peptide from the Klotho gene protected rat kidneys from sudden injury by acting on mitochondria. This was tested in cells and animals only — not people yet, so it is too early to...
Diagnostic Performance of [68Ga]Ga-FAPI PET/CT for Differentiating Histologically Confirmed Kidney Fibrosis Severity in Advanced Chronic Kidney Disease
This study tested a special scan, called FAPI PET/CT, to see how much scarring is inside the kidneys of people with advanced kidney disease. Scarring is what slowly destroys kidney...
Factors Beyond High-Molecular-Weight Toxin Removal That Might Affect Survival in Comparisons of High-Volume Hemodiafiltration with Hemodialysis
This is a review essay about why one form of dialysis, high-volume hemodiafiltration, has looked better for survival than standard hemodialysis in some trials. The usual...
Mfn2-related mitochondrial dysfunction regulates renal fibrosis through ferroptosis in chronic kidney disease.
In test tubes and animals, scientists found that faulty mitochondria can trigger a type of cell death called ferroptosis, which may drive kidney scarring — but this has not been...
Visceral adipose stem cell-derived small extracellular vesicles inhibit EMT in renal tubular epithelial cells and attenuate diabetic kidney fibrosis.
In cells and animals, tiny particles from fat stem cells reduced kidney scarring in diabetic disease by blocking a process called epithelial-mesenchymal transition — but no human...
Heterozygous truncating variants in <i>BICC1</i> are a novel cause of autosomal-dominant tubulointerstitial kidney disease
Scientists found that certain gene changes in the BICC1 gene can cause a rare inherited kidney disease in families, based on lab analysis of DNA from affected people. This was not...
Clinical features of Escherichia coli positive calcium oxalate stones and effects of outer membrane vesicles on tubular epithelial injury and crystal adhesion
Some kidney stones made of calcium oxalate carry E. coli bacteria. Researchers looked at patients with these stones, then tested tiny bubbles shed by the bacteria on kidney tubule...
Advancing dialysis technology to reduce the impact on global warming
This is a review article on making dialysis machines and supplies less damaging to the environment, covering water use, plastic waste, and energy. Dialysis uses large amounts of...
Molecular Insights into gene expression changes in apoptosis immune response and cellular regulation pathways in renal failure patients
Researchers compared which genes were switched on or off in people with kidney failure, focusing on genes tied to cell death, immune response, and basic cell housekeeping. This is...
Perirenal Hematoma and Graft Malposition Requiring Surgical Repositioning After Transplant Tourism: A Case Report
A patient traveled abroad to buy a kidney transplant. After coming home, doctors found bleeding around the new kidney and the organ sitting in the wrong position, so they operated...
Hepatitis B in Organ Transplantation-Current Evidence and Clinical Gaps.
This review covers hepatitis B in people who get organ transplants, including kidney transplants. Antiviral pills have turned outcomes from poor to very good, and vaccination has...
Infected wound in a lower extremity hematoma in a patient with thrombocytopenia after renal transplantation.
A kidney transplant patient developed an infected pool of blood in the leg. The anti-rejection drugs had dropped their platelet count, the blood cells that stop bleeding, so...
Are We Winning at Twinning? Persistent CNI Use in Identical Kidney Transplants.
An identical twin transplant is the one case where the donated kidney matches the body exactly, so anti-rejection drugs should not be needed. Researchers looked back at transplant...
HLA-A, -B, and DR Mismatch and Outcomes After Simultaneous Pancreas-Kidney Transplantation in the Modern Era.
In over 1,200 people who received a kidney and pancreas transplant together, more mismatches in immune system markers were linked to higher risk of kidney failure — but this study...
ABO blood group associations with corneal and organ failure diagnoses on the Ecuadorian transplant waiting list: A 2017-2022 observational cohort study.
In 1,042 Ecuadorian patients on the transplant waiting list, blood type O was linked to longer wait times for kidney transplants — but this observational study shows only an...
Aortoiliac calcification assessment via computed tomography in kidney transplantation: correlation with graft outcomes.
This study found that more calcium buildup in the main artery near the kidney transplant site linked to worse graft survival, but because it looked back at past records (not...
Distinguishing autoimmune recurrence from rejection in Simultaneous pancreas-kidney transplantation recipients: a case-based short review.
This short review discusses how to tell apart autoimmune recurrence from rejection after pancreas-kidney transplant, but it only shares two case stories — no data on how often this...
Recurrent Sterile Pleuropericarditis After Withdrawal of Renal Transplant Immunosuppression in Anuric ESRD: A Case of Suspected IL-1-Mediated Autoinflammation.
This case report describes a rare immune reaction after stopping kidney transplant drugs — but it involves only one person, so no conclusions can be drawn about how common or...
Double-J versus single-J stent placement in kidney transplant recipients: a systematic review and meta-analysis of postoperative outcomes
After a kidney transplant, surgeons place a small tube called a stent to keep the connection to the bladder open. This review pooled results from many studies comparing two stent...
Anti-PAR2 autoantibodies are associated with chronic histological injury in kidney transplant recipients
Researchers found that kidney transplant patients carrying a certain self-attacking antibody, called anti-PAR2, were more likely to show long term damage in kidney biopsy samples....
Association of an early postoperative immune frailty index with a 6-month composite of infection and acute rejection in older kidney transplant recipients
Older people who get a kidney transplant face two opposite risks: infection from anti-rejection drugs, and the body rejecting the new kidney. Researchers built an immune frailty...
Donor Self-Esteem Before and After Living Kidney Donation
This study followed people who gave a kidney while alive and asked how donating changed the way they felt about themselves. Most donors already feel good about themselves before...
Should we ligate haemodialysis fistulas in patients once they have been transplanted successfully: a randomised feasibility study for a parallel randomised controlled trial
After a successful kidney transplant, the surgically made arm connection used for dialysis, called a fistula, is no longer needed, and doctors disagree about whether to tie it off....
Advocating for a new U.S. Transplant System
A podcast episode about a proposed U.S. law, the Securing the OPTN Act, which would change how donated organs are matched and shared. Two policy experts explain why the bill was...
Urinary HSP90 as a Non-invasive Biomarker of Active Tubular Injury in Kidney Transplant Recipients: A Multicenter Prospective Study.
Researchers tested whether a protein called HSP90 in urine can show when the body is attacking a transplanted kidney. They collected 262 paired urine and blood samples from 112...
Factors Associated with Poor Knowledge of Chronic Kidney Disease in the General Population of Abomey-Calavi (Benin): A Cross-Sectional Study
A survey in Abomey-Calavi, Benin asked members of the public what they knew about chronic kidney disease. Knowledge was poor overall, and the study looked at which groups knew the...
Time of Day as a Biological Variable in Cardiovascular and Kidney Disease Research: A Scientific Statement From the American Heart Association
The American Heart Association is asking researchers to pay attention to the time of day when they run kidney and heart studies. Blood pressure, hormones and kidney filtering rate...
Chronic Kidney Disease Among Outpatients in a Central European Tertiary Care Centre: High Prevalence and Inadequate Treatment
Doctors at a large Central European hospital checked how common kidney disease was among their outpatients. They found a high share had it, and many were not getting the treatment...
Development and validation of cluster-specific diagnostic models for osteoporosis in chronic kidney disease patients: based on NHANES and CRDS data
Researchers built a tool to predict which people with kidney disease also have thinning, fragile bones (osteoporosis). Kidney disease damages bone, so spotting it early matters for...
The Global Future of Cardiovascular Kidney Metabolic Syndrome Care
This is an opinion piece about how care should be organized worldwide for people whose heart, kidney and metabolic problems all feed each other. Doctors now treat these as one...
The Eye as a Window to Cardio-Kidney-Metabolic Disease
This piece looks at whether an eye exam can reveal heart, kidney and metabolic disease. The tiny blood vessels at the back of the eye can be seen directly, and they may mirror the...
Decoding the urinary metabolome of aromatic amino acid pathways in Alport syndrome
Researchers measured chemical byproducts in the urine of people with Alport syndrome, an inherited kidney disease that runs in families. They focused on the breakdown products of...
Screening for CKD to halt its growing burden in Europe: a political proposal by the Italian Society of Nephrology.
Italy's kidney doctors are proposing that Europe screen people for kidney disease to catch it early. They point to 2025, when the World Health Organization and the United Nations...
Clinical Effectiveness and Resource Use in End-Stage Renal Disease Patients: Remote Patient Monitoring Across Dialysis Modalities
This real-world study will track people starting dialysis in China to see how remote monitoring affects their health, quality of life, and use of healthcare services. There are no...
Overcoming Trial Exclusion: A Multicenter Analysis of Hemodialysis Multiple Myeloma Patients Who Underwent BCMA-Directed CAR-T Therapy.
This study looked back at 8 dialysis patients with cancer who received a new immune therapy (CAR-T) and found they survived about as long as other patients in the study, despite...
Inequalities in outcomes after kidney transplant failure in the UK.
A look at UK records from 2012 to 2021 found that Black and South Asian patients were less likely than White patients to get a new kidney after their transplant failed, but this...
Development and Validation of a Predictive Risk Score for Poor Functional Outcome After Transcatheter Aortic Valve Replacement in Elderly Patients.
Among 204 elderly patients who had heart valve surgery, certain health factors were linked to poor recovery six months later — but this observational study shows only a connection,...
Lupus Nephritis Exhibiting a Membranoproliferative Pattern in Primary Myelofibrosis: A Diagnostic Challenge of Occult SLE.
A rare case report describes a man with bone marrow disease and lupus-like kidney damage — this is one patient only, so it does not prove anything about causes or treatments for...
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) with ocular involvement due to a novel CLDN19 variant.
This case report describes a rare genetic disorder causing low magnesium and kidney stones that can lead to kidney failure, but it does not test any treatment or report outcomes...
Shared Decision-Making in Dialysis Modality Selection Among Adults with Advanced Kidney Disease in Saudi Arabia: A Cross-Sectional Study
This survey in Saudi Arabia asked adults with advanced kidney disease how much say they had in choosing their dialysis type, such as in-center hemodialysis or home peritoneal...
Quantifying inequalities and forecasting the burden of chronic kidney disease from 1990 to 2040
This analysis tracked chronic kidney disease worldwide from 1990 and projects the burden out to 2040. It measures how unevenly the disease falls across countries and income levels,...
Between Survival and Sacrifice: Marital Experiences of Patients Undergoing Hemodialysis
This is an interview study of married people on hemodialysis, describing how treatment reshapes a marriage. Patients described a pull between staying alive and what the schedule...
Machine Learning for Identifying Concurrent Chronic Kidney Disease in Patients with Heart Failure
A computing paper on using machine learning to spot which heart failure patients also have chronic kidney disease. The aim is to flag the two conditions together from data already...