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Chronic Kidney Disease with Sjögren's Syndrome and Hyperthyroidism: Discrepant Creatinine- and Cystatin C-Based eGFR.

Key takeaways

A 70-year-old woman had kidney disease, an overactive thyroid, and Sjogren's syndrome, an immune condition that dries out the eyes and mouth. Her two blood tests for kidney filtering rate (eGFR), one based on creatinine and one on cystatin C, gave very different answers. A kidney biopsy showed long-standing inflammation in the filtering tubes, and treating her thyroid brought the two numbers closer together. This is a report on one patient, so it flags a link worth knowing about, not proof of cause.

Who did this work

Mizuta M · Fukuda M · Fujii M · Fukamura H · Ikeda Y · Kanaya A · Yoshihara M · Aoki S · Miyazono M

Source

Article · PubMed, Climate, heat and the kidney · 2026 Aug 25
https://pubmed.ncbi.nlm.nih.gov/42649068/