← brief for 2026-08-26 · Regeneration & devices

Clinical features of Escherichia coli positive calcium oxalate stones and effects of outer membrane vesicles on tubular epithelial injury and crystal adhesion

Paper D Peer reviewed Preclinical

Key takeaways

Some kidney stones made of calcium oxalate carry E. coli bacteria. Researchers looked at patients with these stones, then tested tiny bubbles shed by the bacteria on kidney tubule cells in the lab. The bubbles injured the cells and made crystals stick more easily. This was cells in the lab, not people, so it only suggests one way stones may take hold.

Who did this work

Xijie Ding (Qinghai University Affiliated Hospital) · Qingchen Du (Qinghai University Affiliated Hospital) · Xinyang Niu (Beijing Tsinghua Chang Gung Hospital) · Endi Zhang (Beijing Tsinghua Chang Gung Hospital) · Jianxing Li (Beijing Tsinghua Chang Gung Hospital) · Guojun Chen (Qinghai University Affiliated Hospital) · Chaoyue Ji (Beijing Tsinghua Chang Gung Hospital) · Weiguo Hu (Beijing Tsinghua Chang Gung Hospital)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-20
https://doi.org/10.3389/fcimb.2026.1859506