← brief for 2026-08-26 · Slowing decline

Exploratory Mediation-Informed Analysis and Dose-Response Analysis of Uric Acid Reduction and Kidney Outcomes in SGLT2 Inhibitor Therapy Compared to Allopurinol.

Article C Peer reviewed Observational

Key takeaways

A retrospective study of diabetics with high uric acid found that those taking SGLT2 inhibitors had lower uric acid and better kidney outcomes than those on allopurinol, but because it looked back at records, it cannot prove the uric acid drop caused the kidney benefit—only that the two things were linked.

Who did this work

Jámbor T · Tallósy SP · Lantos T · Szabó A · Fejes R

Source

Article · PubMed, CKD progression · 2026 Jul 23
https://pubmed.ncbi.nlm.nih.gov/42646555/