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Factors Beyond High-Molecular-Weight Toxin Removal That Might Affect Survival in Comparisons of High-Volume Hemodiafiltration with Hemodialysis

Key takeaways

This is a review essay about why one form of dialysis, high-volume hemodiafiltration, has looked better for survival than standard hemodialysis in some trials. The usual explanation is that it clears larger waste molecules from the blood. The authors argue other differences between the treatments may explain part of the benefit, such as how much fluid is removed and how stable blood pressure stays during the session. It is an argument about existing trials, not new data, so there are no results here.

Who did this work

John T. Daugirdas (University of Illinois Chicago)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-25
https://doi.org/10.3390/toxins18090365