← brief for 2026-08-26 · Slowing decline

Glucagon-Like Peptide 1 Receptor Agonists, Mortality, and Cardiovascular Outcomes in Serious Mental Illness.

Article C Peer reviewed Observational

Key takeaways

A review of 1.2 million adults with serious mental illness found those who took GLP-1 drugs had about a 20% lower risk of death or major heart problems over two years compared to those on SGLT2 inhibitors, but because it was an observational study, it shows a link—not proof the drug caused the benefit.

Who did this work

McIntyre RS · Zhang-James Y · Kwan ATH

Source

Article · PubMed, the drug frontier · 2026 Aug 26
https://pubmed.ncbi.nlm.nih.gov/42647034/