← brief for 2026-08-26 · Slowing decline

Heterozygous truncating variants in BICC1 are a novel cause of autosomal-dominant tubulointerstitial kidney disease

Key takeaways

Some families pass down a slow kidney disease that usually leads to kidney failure around age 45, with no protein in the urine and few other warning signs. Researchers found broken copies of a gene called BICC1 in several of these families, giving them a genetic diagnosis they did not have before. This links the gene to the disease but does not prove how it causes the damage. The report is a preprint and has not been peer reviewed.

Source

Preprint · medRxiv nephrology preprints · 2026-08-23
https://www.medrxiv.org/content/10.64898/2026.08.20.26360556v1?rss=1