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Integrative transcriptomic and single-cell analysis identifies anoikis-related molecular signatures in vascular calcification

Paper D Peer reviewed Preclinical

Key takeaways

Researchers sifted gene activity data, including readings from single cells, to find molecular patterns in blood vessels that have hardened with calcium. That hardening is common in kidney disease and raises heart risk. They flagged genes tied to anoikis, a kind of cell death that happens when a cell loses its grip on the tissue around it. This is computer and lab work, not a study in people, so it gives leads only.

Who did this work

Dandan Chen (Mengchao Hepatobiliary Hospital) · Tianzeng Dai (Mengchao Hepatobiliary Hospital) · Wenfeng Yu (Mengchao Hepatobiliary Hospital) · Xi'na Xie (Mengchao Hepatobiliary Hospital) · Rui Rui (Mengchao Hepatobiliary Hospital) · Yan Wang (15435) (Mengchao Hepatobiliary Hospital)

Source

Paper · OpenAlex, CKD works · 2026-08-24
https://doi.org/10.1080/0886022x.2026.2704989