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Kidney disease progression during and after pregnancy in a Col4a3-/- mouse model of Alport syndrome: an experimental study

Paper D Peer reviewed Preclinical

Key takeaways

This study looked at whether pregnancy speeds up kidney damage in Alport syndrome, an inherited disease that attacks the kidney's filters. It was done in mice bred to carry the same gene fault, not in women. The researchers tracked kidney decline both during pregnancy and after it ended. Mouse results do not transfer directly to people, but this question is hard to study in humans, so it is a useful starting point.

Who did this work

Xinxin Kong (Peking University) · Fang Wang (Peking University) · Yuanyuan Ma (Peking University) · Jie Ding (Peking University) · Yanqin Zhang (Peking University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-20
https://doi.org/10.1186/s12882-026-05249-6