← brief for 2026-08-26 · Regeneration & devices

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Paper D Peer reviewed Preclinical

Key takeaways

A peptide from the Klotho gene protected rat kidneys from sudden injury by acting on mitochondria. This was tested in cells and animals only — not people yet, so it is too early to know if it helps humans.

Who did this work

Xiaoyao Zhang (Guangdong Provincial People's Hospital) · Shihui Lin (Guangdong Provincial People's Hospital) · Tianyu Wu (Guangdong Provincial People's Hospital) · Zhixin Zhang (Guangdong Provincial People's Hospital) · Hong Zhou (Guangdong Provincial People's Hospital) · Xue Hong (Guangdong Provincial People's Hospital) · Youhua Liu (Guangdong Provincial People's Hospital)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-25
https://doi.org/10.1002/advs.77214