← brief for 2026-08-26 · Regeneration & devices

MANF clears mutant uromodulin in human kidney organoids of autosomal dominant tubulointerstitial kidney disease.

Article D Peer reviewed Preclinical

Key takeaways

In lab-grown human kidney organoids from patients with a rare inherited disease, a protein called MANF cleared mutant uromodulin and reduced cell stress, but this has not been tested in people yet.

Who did this work

Gu C · Fang Y · Wang Y · Tycksen E · Kondepati G · Li C · Kidd KO · Liu J · Urano F · Lindahl M · Bleyer AJ · Singamaneni S

Source

Article · PubMed, organoids & devices · 2026 Aug 25
https://pubmed.ncbi.nlm.nih.gov/42640736/