← brief for 2026-08-26 · Regeneration & devices

Mfn2-related mitochondrial dysfunction regulates renal fibrosis through ferroptosis in chronic kidney disease.

Key takeaways

In test tubes and animals, scientists found that faulty mitochondria can trigger a type of cell death called ferroptosis, which may drive kidney scarring — but this has not been tested in people yet.

Who did this work

Zhang M (Department of Nephrology, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.) · Wang J (Renal Division, Peking University First Hospital, Beijing, 100034, People's Republic of China.) · Yang Y (Department of Nephrology, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.) · Ma Y (Department of Nephrology, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.) · Huang J (Department of Nephrology, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.) · Geng H (Department of Nephrology, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China.) · Bai X (Laboratory of Epigenetics, School of Life Sciences, China Medical University, Shenyang, 110001, People's Republic of China. Electronic address: baixiao@cmu.edu.cn.) · Shang W (Laboratory of Epigenetics, School of Life Sciences, China Medical University, Shenyang, 110001, People's Republic of China. Electronic address: whshang@cmu.edu.cn.) · Sun L (Department of Nephrology, The First Hospital of China Medical University, Shenyang, 110001, People's Republic of China. Electronic address: sunlicmu1974@163.com.)

Source

Paper · Europe PMC, CKD · 2026-08-24
https://doi.org/10.1016/j.bbadis.2026.168432