← brief for 2026-08-26 · Slowing decline

Safety & efficacy of sodium glucose co-transport 2 (SGLT2) inhibitors in elderly patients with heart failure

Paper A Peer reviewed Meta-analysis or large trial

Key takeaways

SGLT2 inhibitors are pills first made for diabetes that also protect the heart and kidneys. This review pooled trial data on older adults with heart failure and found they cut hospital stays and deaths from heart causes, with safety much like younger patients. Side effects to watch were genital infections and dehydration. Most people with kidney disease also have heart disease, so this matters for both.

Who did this work

Anis Nabila Mohamad (University Kebangsaan Malaysia Medical Centre) · Chandini Menon Premakumar (University Kebangsaan Malaysia Medical Centre) · Abdullah Faiz Zaihan (Universiti Teknologi MARA System) · Suharzelim Abu Bakar (Sultan Idris Education University) · Shairyzah Ahmad Hisham (University of Nottingham Malaysia Campus)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-20
https://doi.org/10.3389/fcvm.2026.1882576