← brief for 2026-08-26 · Slowing decline

Targeting Runx1 Slows Cyst Growth in Autosomal Dominant Polycystic Kidney Disease

Key takeaways

Blocking a protein called Runx1 slowed the growth of kidney cysts in polycystic kidney disease, an inherited condition where fluid-filled sacs crowd out working kidney tissue. This was done in animals or cells, not in people yet. It points to a possible new drug target, but nothing here tells us it would help a patient. The abstract was not available, so the exact models and dose are not known here.

Who did this work

Yueyue Zhang (Mayo Clinic) · Chang Liu (Mayo Clinic) · Junchi Liu (Mayo Clinic) · Xiaoyan Li (Mayo Clinic) · Vicente Torres (Mayo Clinic) · Xiaogang Li (Mayo Clinic) · Julie Zhou (Mayo Clinic)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-25
https://doi.org/10.1096/fj.202600741r