← brief for 2026-08-26 · Slowing decline

Twist Family BHLH Transcription Factor 1 orchestrates hypoxia-lactate crosstalk to bridge glycolytic flux and tubular maladaptation in fibrotic kidneys

Paper D Peer reviewed Preclinical

Key takeaways

In test tubes and animals, a protein called Twist1 was found to help link low oxygen and sugar use in kidney cells during scarring, but this work has not been tested in people yet. It may inform future drug development, but no human kidney benefit is proven.

Who did this work

Zhixiang Yu (Chinese PLA General Hospital) · Yuzhan Zhang (Xijing Hospital) · Bai Xiao (Xijing Hospital) · Jin Zhao (Xijing Hospital) · Lei Wei (Xijing Hospital) · Jingli Gao (Xijing Hospital) · Hao Wu (Xijing Hospital) · Rui Ma (Xijing Hospital) · Xiaoxuan Ning (Xijing Hospital) · Shiren Sun (Xijing Hospital)

Source

Paper · OpenAlex, CKD works · 2026-08-24
https://doi.org/10.1186/s43556-026-00555-9