← brief for 2026-08-26 · Transplant & xeno

Urinary HSP90 as a Non-invasive Biomarker of Active Tubular Injury in Kidney Transplant Recipients: A Multicenter Prospective Study.

Key takeaways

Researchers tested whether a protein called HSP90 in urine can show when the body is attacking a transplanted kidney. They collected 262 paired urine and blood samples from 112 transplant patients across several hospitals, looking for the common type of rejection that inflames the kidney's tubes. A urine test would be far easier than a biopsy, which takes a piece of the kidney with a needle. This kind of study shows a link between the protein and rejection, not proof that the test works in practice.

Who did this work

Tachikawa K · Tanaka T · Maehana T · Shindo T · Kyoda Y · Hashimoto K · Nishida H · Kitamura H · Tsuji T · Masumori N

Source

Article · PubMed, Climate, heat and the kidney · 2026 Aug 26
https://pubmed.ncbi.nlm.nih.gov/42648627/