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Vascular Dysfunction in Renal Injury and Cognitive Dysfunction: The Central Role of Endothelin-1

Key takeaways

This is a review of lab and animal work on endothelin-1, a natural substance that makes blood vessels tighten. The authors argue it is a shared driver of both kidney damage and thinking problems, because stiff, leaky vessels harm the kidney filters and the brain alike. This is a summary of preclinical science, not a study in people, so it does not show that blocking endothelin-1 protects memory. It matters because endothelin-blocking drugs are already being tested in kidney disease.

Who did this work

Marice McCrorey (Medical University of South Carolina) · Lada Palygina (Medical University of South Carolina) · Helen M Butler (Medical University of South Carolina) · Justin Van Beusecum (Medical University of South Carolina)

Source

Paper · OpenAlex, CKD works · 2026-08-19
https://doi.org/10.1139/cjpp-2026-0030