← brief for 2026-08-26 · Regeneration & devices
Visceral adipose stem cell-derived small extracellular vesicles inhibit EMT in renal tubular epithelial cells and attenuate diabetic kidney fibrosis.
Key takeaways
In cells and animals, tiny particles from fat stem cells reduced kidney scarring in diabetic disease by blocking a process called epithelial-mesenchymal transition — but no human trials have been done.
Who did this work
Yu J (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China.) · Hong X (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China.) · Zhu T (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China.) · Lin J (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China.) · Du Y (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China.) · Dai J (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China.) · Luo S (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China.) · Yan L (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China.) · Ren M (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China.) · Sun K (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China. Electronic address: skendo@163.com.) · Zeng T (Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou 510120, China; Guangdong Clinical Research Center for Metabolic Diseases, Guangzhou 510120, China. Electronic address: zengtt6@mail.sysu.edu.cn.)
Source
Paper · Europe PMC, CKD · 2026-08-24
https://doi.org/10.1016/j.bcp.2026.118395