Kidney research, 2026-09-11
Today brought little new kidney research, and what came in is early
-
That fluid study measured everyone at a single moment, so it points at an idea worth testing rather than giving you something to act on.
-
A separate review argued that diet is getting less attention as new kidney drugs arrive, which is an opinion piece and not new evidence.
Today was a quiet day for kidney research, with only two items worth mentioning and neither one strong. The one graded study links body fluid levels to nutrition and physical strength in people with chronic kidney disease, though its design can only show that these things travel together. Its own authors describe it as hypothesis generating, meaning a real trial would still be needed. Nothing today should change how you eat, take your medicines, or manage fluid without talking to your kidney team first.
Spontaneous All-Sequence Baroreflex Sensitivity Across Predialysis Chronic Kidney Disease Categories: A Cross-Sectional Study.
Your body has a reflex that adjusts your heart rate when your blood pressure changes. This study measured how well that reflex works in people with kidney disease who are not yet...
RIPK3 promotes G2/M cell cycle arrest in renal tubular epithelial cells for maladaptive kidney repair.
After a sudden kidney injury, the small tubes in the kidney sometimes heal badly, and that bad healing turns into scarring and long term kidney disease. This study found a protein...
Sports Nephrology: Managing Hypertension, Acute Kidney Injury, and Cardiovascular Risk in a Collegiate Football Player.
A 19 year old college football player had high blood pressure that would not come down with treatment, plus a recent kidney injury from losing too much body fluid. Testing found he...
Phosphate storm in chronic kidney disease-mineral and bone disorder: practical clinical strategies for vascular calcification control.
This is a review of how too much phosphate in the blood drives calcium buildup inside blood vessels when kidneys fail. It walks through why the usual tools, phosphate binders and...
Vitamin D alleviates indoxyl sulfate-induced inflammatory and cholesterol dysregulation in macrophages: Implications for vascular health in patients receiving hemodialysis.
Indoxyl sulfate is a waste product that builds up when kidneys fail and that damages blood vessels, which matters for people on dialysis. Researchers put this toxin on immune cells...
Protein mediators of chronic kidney disease in Type 2 diabetes: A mendelian randomization study.
Kidney disease shows up in 20 to 50 percent of people with type 2 diabetes, and it is the top cause of kidney failure worldwide. Scientists used gene data from very large groups to...
Determinants of biochemical factors and microalbuminuria among type 2 diabetes mellitus patients.
This study compared 90 healthy people against people who had type 2 diabetes, some for less than five years and some for more than five. It measured fasting blood sugar, HbA1c (a...
Sparsentan - SGLT2 inhibitor combination therapy in trials of IgA nephropathy.
Sparsentan is a drug that blocks two separate signals that raise pressure inside the kidney filters. This report tests it alongside SGLT2 inhibitors, diabetes drugs that also...
Obesity and Cardio-Metabolic Health in Kidney Disease: Implications for Kidney Health, Risk Stratification, and Management.
This is a review article, not a new study. It explains how extra body weight harms kidneys directly, by making the filters work too hard and raising pressure inside them, and...
A dual role of AcSDKP in chronic kidney disease: Targeting pericyte-driven fibrosis and vascular repair via VEGF/FGFR1 while eliciting a compensatory FGFR1 upregulation in apoptotic tubular cells.
Researchers tested a peptide the body makes on its own, called AcSDKP, in mice with kidney damage caused by a toxic plant acid. The peptide reduced scarring and helped protect the...
Clinical Factors Associated with Short-Term Decline in Estimated Glomerular Filtration Rate in People Living with HIV Receiving Antiretroviral Therapy: A Prospective Cohort Study
This study followed people with HIV on standard treatment and found that higher blood pressure, older age, and lower starting kidney filtering rate (eGFR) were linked to a faster...
Circulating Soluble Thrombomodulin Is Elevated in Early-Stage CKD and Is Associated with Renal Dysfunction: A Transcriptomic and Retrospective Cohort Study
A study of people with early kidney disease found higher levels of a protein in the blood linked to worse kidney filtering rate (eGFR), but this only shows a connection — it does...
Development of a multivariable clinical prediction model for acute kidney injury after valve replacement surgery: incremental value of the triglyceride-glucose body mass index.
This study found that a simple score combining triglycerides, blood sugar, and body mass index (TyG-BMI) helped predict who would get sudden kidney injury after heart valve...
Low baseline HbA1c and reduced eGFR are associated with relatively unfavorable body recomposition after SGLT2 inhibitor therapy in type 2 diabetes.
In people with type 2 diabetes on SGLT2 inhibitors, those with lower blood sugar and worse kidney filtering rate (eGFR) at the start tended to lose more fat but also more muscle...
Effects of GLP-1 receptor agonists on the incidence of contrast-induced acute kidney injury in patients with Type 2 diabetes mellitus undergoing coronary interventions.
This observational study found that type 2 diabetes patients who took GLP-1 drugs before heart procedures had less sudden kidney injury after contrast dye was used, but because it...
Cardiorenal Protection in Type 2 Diabetes: A Systematic Review Comparing Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors.
This systematic review looked at many large trials and found both GLP-1 receptor agonists and SGLT2 inhibitors slow kidney decline and lower heart risks in type 2 diabetes, even...
Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective.
This review lays out treatment goals for primary biliary cholangitis, a liver disease where the immune system attacks the small bile ducts. It is written for doctors in Australia....
Dapagliflozin inhibits renal mesangial cell fibrosis by regulating HO-1/TGF-β1/Smad 2/3 axis.
This lab study tested dapagliflozin, an SGLT2 inhibitor already used in kidney disease, on kidney cells to work out how it reduces scarring. Scarring is the stiff tissue that...
Blood pressure and cardiovascular risk in adults with non-proteinuric chronic kidney disease without diabetes.
This Japanese study followed 287,238 adults with reduced kidney filtering rate (eGFR under 60) who had no diabetes and little or no protein in their urine. It compared blood...
The SGLT2i Treatment Gap in UK Primary Care: A Cross-Sectional RWE Study of Prescribing in Clinical Practice.
This UK study looked at family doctor records to count people who qualify for SGLT2 inhibitors but are not taking them. These are pills that protect the kidneys and heart in type 2...
Complement in Kidney Disease: Core Curriculum 2026
This is a teaching review about complement, a part of the immune system that fights infection but can also attack the kidney when it misfires. It explains that the US Food and Drug...
Demographic and clinical characteristics of rapidly progressive glomerulonephritis in renal vasculitis in the Japan renal biopsy registry
Doctors in Japan pulled cases from a national registry of kidney biopsies, the small tissue samples taken to diagnose kidney disease. They described who gets a fast moving kidney...
Association of Serum 1,25-Dihydroxyvitamin D Levels with Erythropoietin Resistance Index-Based Relative Erythropoiesis-Stimulating Agent Hyporesponsiveness in Pre-Dialysis Chronic Kidney Disease
Many people with kidney disease get anemia, meaning low red blood cells, and take drugs that push the body to make more. Some people respond poorly to those drugs. This study...
Tailored B-cell monitoring in podocytopathies: a necessary shift in practice
This is an opinion piece arguing that doctors should track B cells, a type of immune cell, more closely in podocytopathies. Podocytopathies are kidney diseases that damage the...
Nephroprotective Effects of Carvedilol and Sodium Copper Chlorophyllin in Glycerol-Induced Acute Kidney Injury in Female Rats
Researchers gave female rats carvedilol, a blood pressure drug, and sodium copper chlorophyllin, a chlorophyll-based compound, before causing sudden kidney injury with glycerol....
What are the latest guidelines for hyperkalaemia in adults?
This is a short guideline summary on treating high blood potassium, called hyperkalaemia, in adults. High potassium is a common and dangerous problem in kidney disease, because...
Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury
Apelin-13 is a small natural peptide. Giving it before cutting off and then restoring blood flow to the kidney reduced the scarring that followed in older animals. Scarring is what...
Hyperglycaemia-induced molecular reprogramming of proximal tubular epithelial cells and its contribution to diabetic kidney disease progression—a narrative review
This is a review article, not a new study. It walks through how high blood sugar changes the cells lining the kidney's small tubes, and how those changes push diabetic kidney...
Complement diagnostics and therapeutics for the pediatric population: early successes and opportunities for further advancement
This review covers tests and drugs that target the complement system in children. The complement system is part of the immune defense, and when it misfires it can attack the...
Oxidative Stress and Renal Function in Severe Preeclampsia and Normal Pregnancy
This study compared kidney function and signs of cell damage from unstable oxygen molecules in women with severe preeclampsia against women with normal pregnancies. Preeclampsia is...
Metal Homeostasis Imbalance as Potentially Contributing Mechanism in Onset of Cardiac Disorders in Individuals with Chronic Obstructive Pulmonary Disease and Chronic Kidney Disease
This study looked at whether an imbalance of metals in the body, things like zinc, copper and iron, is linked to heart problems in people who have both chronic lung disease and...
The Role of Thiazide Diuretics in Hypertension with Chronic Kidney Disease: Benefits and Risks
This is a review article about thiazides, a common type of water pill used to lower blood pressure. It weighs the benefits against the risks for people who have both high blood...
Exploring the Mechanism of Action of Danggui Buxue Decoction in Treating Chronic Glomerulonephritis Based on UPLC-MS/MS and Network Pharmacology.
Danggui Buxue Decoction is a two herb Chinese medicine formula used for chronic glomerulonephritis, a long running inflammation of the kidney filters. Researchers identified the...
Wheat Bran Stir-Frying Reshapes the Metabolome of Euryale Ferox Seeds and Predicts Enhanced Bioactive Potential for Spleen and Kidney Tonifying
Scientists tested how cooking mung beans changes their chemicals in the test tube and predicted they might help kidneys, but no people or animals were studied yet. This is early...
Prevalence and factors associated with malnutrition among patients with pre-dialysis chronic kidney disease stages 3-5.
This cross-sectional study found that nearly half of people with pre-dialysis kidney disease stages 3 to 5 had malnutrition, and lower income, worse kidney filtering rate (eGFR),...
Enhanced Recovery After Surgery (ERAS) Versus Standard Postoperative Care in Elective Craniotomy for Brain Tumor Excision: A Comprehensive Review of Protocol Differences, Clinical Outcomes, and Implementation Challenges.
This review compares standard recovery care after brain tumor surgery with a structured program called Enhanced Recovery After Surgery. The newer approach cuts back on strong...
Climate Change and Cardiovascular Complications of Diabetes.
This is a discussion piece about how heat waves, cold snaps, and air pollution raise heart and kidney risk for people with diabetes. It notes that people with diabetes handle heat...
LIFESTYLE AND DIETARY MODIFICATIONS TO PREVENT THE PROGRESSION OF CHRONIC KIDNEY DISEASE (CKD)-A RANDOMIZED CONTROLLED TRIAL ON MIDDLE AGED DIABETIC POPULATION IN DHAKA CITY, BANGLADESH
Researchers in Dhaka, Bangladesh report a randomized trial of diet and lifestyle changes in middle aged people with diabetes, to see if it slows kidney disease. The record released...
Modern pharmacological therapies in nephrology: Progress, promises, and the forgotten role of diet.
This is an opinion and review article, not a study, so there are no new results. The authors argue that new drugs for obesity, type 2 diabetes and chronic kidney disease work well,...
Fluid status, malnutrition and physical function relationship in chronic kidney disease: A cross-sectional observational pooled analysis study.
This study asked whether carrying too much or too little body fluid goes along with poor nutrition and weaker physical function in people with chronic kidney disease. Fluid levels...
Managing headache in primary care: choosing therapies that treat the whole patient.
This review gives family doctors a practical way to treat headaches while taking a patient's other long-term conditions into account. The goal is to use fewer drugs at once and...
Ayurveda in Contemporary Clinical Practice: Integrating Traditional Principles With Preventive, Metabolic, and Mind-Body Medicine.
This article argues that Ayurveda, a traditional Indian system of medicine, could fit into modern care for long-term and stress-related illness. The authors describe its approach...
Evidence Summary of Pruritus Management in Patients With Atopic Dermatitis: Implications for Nursing Practice
This is a summary of the evidence on treating itching in people with eczema, written for nurses. It pulls together existing guidance rather than testing anything new. No abstract...
Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.
This review describes how the brain washes out waste through a drainage network, including the glymphatic system and lymph vessels in the brain's lining. Scientists once thought...
Mild Cognitive Impairment Diagnosis and Care Algorithms and the Role of Digital Interventions: Expert Consensus.
A group of brain specialists in Asia agreed on how doctors should spot and treat mild memory and thinking problems, called mild cognitive impairment. They also discussed apps and...
Mindfulness for Saudi Hemodialysis Patients
This is a registration for a study that is starting in Saudi Arabia, so there are no results yet. It plans to test whether guided mindfulness sessions during dialysis improve...
Association of adverse adulthood experiences with cardiovascular kidney metabolic syndrome
This study looked at hard experiences in adult life, such as abuse, money trouble, or losing a home. It checked whether people who went through more of them were more likely to...
A Circulating Proteomic Signature of Allostatic Load Is Associated with Multisystem Disease and Mortality
Researchers found a pattern of proteins in the blood that tracks with allostatic load, which is the wear and tear the body takes from long-term stress. People with that protein...
How we do it: functional magnetic resonance urography in congenital anomalies of the kidney and urinary tract
Doctors explain how they run a special MRI scan, called functional MR urography, in children born with problems in the kidneys or urinary tract. The scan shows both the shape of...
Hot Topics In Kidney Health: An Interview With J. Harrison Ghee: “Help Through Community is Key”
Broadway performer J. Harrison Ghee talks about living with kidney disease and looking for a living kidney donor. The interview covers paying attention to your body, asking people...
Gut Microbiota in Kidney Transplantation: Mechanistic Insights and Implications for Precision Immunosuppression.
This is a review of what is known about gut bacteria and kidney transplants, not a new study. It describes how the mix of gut bacteria shifts after a transplant, with less variety...
Supporting data for: Metabolic Bariatric Surgery as a Bridge to Kidney Transplantation in Patients with Obesity and Advanced Kidney Disease: A Systematic Review and Meta-Analysis
This is the data file behind a review that pooled results from many earlier studies. It looked at weight loss surgery for people with obesity and advanced kidney disease who want a...
Clinical implications of cardiovascular events in older kidney transplant recipients: a nationwide cohort study
This nationwide study followed older adults who received a kidney transplant and tracked heart problems such as heart attacks and strokes. The aim was to see what those events mean...
Post-Transplant Diabetes Mellitus Risk After Kidney Transplantation
This is a file posted to a public repository about the risk of developing diabetes after a kidney transplant. Diabetes that starts after a transplant is common and is driven partly...
Performance of the iBox Prognostication System in African American Kidney Transplant Recipients
The iBox is a calculator that predicts how long a transplanted kidney will keep working. This study checked how well it performs in African American transplant recipients, a group...
J. Harrison Ghee Isn’t Letting Kidney Failure Stop Them From Living
J. Harrison Ghee, a Tony and Grammy winning performer, found out they had kidney disease in 2022 while feeling young and healthy. Within four years their kidneys failed, and they...
Early-onset gout is associated with an increased risk of genitourinary cancers in a nationwide cohort of 6.5 million young Korean adults
A study of 6.5 million young Korean adults found that people with early gout were more likely to be diagnosed with genitourinary cancers later, but this does not prove gout causes...
Perceived Child Vulnerability and Protective Behavior by Parents of Children with Chronic Kidney Disease
Researchers asked parents of children with long term kidney disease how fragile they believe their child to be. They then looked at whether that belief changes how protective the...
Patient-reported ratings of transfer to adult care among young adults with chronic kidney disease
Young adults with chronic kidney disease were asked to rate how their move from children's care to adult care went. This handoff is a known weak point, and young people often lose...
Chronic Kidney Disease and Clinical Outcomes in Patients With Multiple Myeloma: A Multicenter Real-World Cohort Study
This study followed people with multiple myeloma, a blood cancer, across several hospitals and compared those who also had chronic kidney disease. Myeloma often damages the...
Genetic Kidney Diseases: What to Know About Inherited Kidney Conditions
This is a plain-language guide from the National Kidney Foundation explaining inherited kidney conditions. It covers what genetic kidney disease is, the main types, what a risk...