← brief for 2026-09-11 · Slowing decline

RIPK3 promotes G2/M cell cycle arrest in renal tubular epithelial cells for maladaptive kidney repair.

Key takeaways

After a sudden kidney injury, the small tubes in the kidney sometimes heal badly, and that bad healing turns into scarring and long term kidney disease. This study found a protein called RIPK3 was raised in the tube cells of damaged kidneys, and that it stalls those cells partway through dividing. Stalled cells then send out signals that drive scarring. The work used kidney tissue samples and lab models, and no treatment was tested in people.

Who did this work

Xie Z · Li L · Liang H · Chen Y · Li Z · Zhang L · Luo J · Zhao X · Chen Y · Dong W · Liang X

Source

Article · PubMed, CKD progression and prevention · 2026 Sep 11
https://pubmed.ncbi.nlm.nih.gov/42725810/