← brief for 2026-09-17 · Slowing decline

Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial.

Key takeaways

This is a plan for a new trial called THINK. It will test if adding a diuretic, or water pill, is the best next step for people with kidney disease and high blood pressure. There are no results yet because the study is just starting. This is important because high blood pressure hurts the kidneys.

Who did this work

Le Vilain-Abraham F · Halimi JM · Rossignol P · Laville M · Azizi M · Stengel B · Maisons V · Rouzès A · Caille A · Sautenet B

Source

Article · PubMed, CKD nutrition RCTs · 2026 Sep 17
https://pubmed.ncbi.nlm.nih.gov/42754276/