Kidney research, 2026-09-17
Salt and blood sugar links offer new clues for kidney care.
Today's news focuses on observational studies that show links between diet, blood sugar, and kidney health. These findings help doctors identify risks but do not prove direct causes. A new trial is also starting to test how best to lower blood pressure in kidney patients.
Examining the multidimensional implications of oral health in chronic kidney disease: A systematic review.
This review looks at the link between kidney disease and oral health. It covers 46 studies on how kidney issues affect teeth and gums. It is a summary of past research, not a new...
Redefining weight management after liver transplantation with glucagon-like peptide one and gastric inhibitory polypeptide receptor agonists.
This review discusses using weight loss drugs to help people after liver transplants. It looks at how these drugs might protect the kidneys and prevent diabetes. It is a summary of...
Impact of Combination Therapy With Caffeine and Naringin on Insulin Resistance and Renal Function in a Nonalcoholic Fatty Liver Disease Rat Model.
This study tested a mix of caffeine and naringin in rats. The animals had fatty liver disease caused by a high-fat diet. The researchers looked at how this mix affected insulin...
Characterization of the neoprotein MUC1-fs in patient-derived cells with ADTKD-MUC1
ADTKD-MUC1 is an inherited kidney disease that often leads to kidney failure in middle age. A faulty gene makes an abnormal protein called MUC1-fs, and it builds up in kidney tube...
Comparative Cardiorenal Efficacy and Safety of Finerenone, SGLT2 Inhibitors, Semaglutide and Their Combination in Diabetic Kidney Disease.
This review pooled 10 sets of randomized trial data from adults with type 2 diabetes and kidney disease. It compared four options for protecting the kidneys and heart: finerenone,...
Diosmetin Restores Endoplasmic Reticulum Homeostasis to Ameliorate Podocyte Injury in Diabetic Kidney Disease by Targeting DNAJC3.
Diosmetin is a natural plant compound found in citrus fruits. Researchers damaged podocytes, the kidney's filter cells, with high sugar and fat in the lab to mimic diabetic kidney...
Albumin-Corrected Serum Calcium as a Biochemical Correlate of Left Ventricular Dysfunction Among Patients With End-Stage Renal Disease on Maintenance Hemodialysis: A Cross-Sectional Study
This study looked at people with kidney failure on regular hemodialysis (blood-cleaning treatment by machine). It checked whether their blood calcium level, adjusted for a blood...
Clinical application of sugammadex in renal impairment: pharmacokinetics and pharmacodynamics
This article looks at sugammadex, a drug used after surgery to reverse muscle-relaxing medicines, in people whose kidneys do not work well. It covers how the body clears the drug...
Association Between Serum Biochemical Parameters and Kidney Stone Disease: An Exploratory Analysis of the 2017-2018 National Health and Nutrition Examination Survey (NHANES)
Researchers used data from a large US health survey (NHANES, 2017 to 2018) to see which blood test results line up with kidney stones. It is an exploratory study, meaning it looked...
Intercalated cells contribute to the immune responses in renal autoimmune disease
This paper looks at whether intercalated cells, a type of cell in the kidney's small tubes that helps balance acid, also play a part in the immune attack in autoimmune kidney...
RESISTENCIA A LA INSULINA EN LA DIABETES MELLITUS TIPO 2 Y SU PAPEL EN LA PROGRESIÓN DE LA ENFERMEDAD RENAL CRÓNICA Y LAS COMPLICACIONES CARDIOVASCULARES: UNA REVISIÓN NARRATIVA CRÍTICA CON BÚSQUEDA ESTRUCTURADA
This Spanish-language review article looks at how insulin resistance in type 2 diabetes may speed up kidney decline and heart problems. Insulin resistance means the body responds...
Bardet–Biedl Syndrome Presenting with End-Stage Kidney Disease: A Case Report
This report describes one patient with Bardet-Biedl syndrome, a rare inherited condition, whose kidneys had already failed when the illness was found. A report on one person cannot...
Influence of Chronic Kidney Disease on Outcomes After Paclitaxel-Coated Balloon Angioplasty for Coronary In-Stent Restenosis
This study looked at people with kidney disease who had a heart procedure to open blocked arteries. It shows a link between kidney health and how well the heart procedure works. It...
Targeting DPP9 attenuates podocyte injury by regulating NRF2 antioxidant signaling
This study examined how a drug called finerenone protects kidney cells from damage. It found that the drug works by reducing stress in the cells. This research was done in cells...
CD4+ T cell subset imbalance contributes to diabetic kidney disease progression: immunopathological mechanisms and targeted therapeutic strategies
This review explains how the immune system drives kidney damage in diabetes. It looks at specific white blood cells that cause inflammation and scarring. There are no new results...
Initial Changes in eGFR during Treatment with Balcinrenone and Dapagliflozin
This study looked at 324 people with kidney disease who started a new drug combo. It checked how their kidney filtering rate changed in the first few weeks. The goal was to see if...
Distinct renal adverse event profiles among CDK4/6 inhibitors: a comparative pharmacovigilance analysis
This study looked at safety reports for three cancer drugs. It found that each drug has a different pattern of kidney side effects. This shows a link between the drugs and kidney...
Applications of artificial intelligence in chronic kidney disease: a systematic review.
This review looked at how computer tools help find and manage kidney disease. It checked studies from 2019 to 2025. The review shows these tools can spot problems early. It is a...
Epidemiology of Critically Ill Patients With Cirrhosis Undergoing Continuous Renal Replacement Therapy: A Contemporaneous Parallel Analysis of the HRS-HARMONY and CRRTnet Registries.
This study looked at 245 people with liver disease who needed dialysis in the ICU. It tracked how they were treated and how many died in the hospital. It shows a link between...
Single genetic trigger model of CKD-associated cardiac remodeling in podocyte-specific MafB knockout mice
This study used mice with a specific gene change to mimic kidney disease. The mice developed heart changes that match human kidney disease. This was in animals, not people yet. It...
Highly viscous ascites prompting reconsideration of cardiorenal syndrome in a patient with advanced CKD after TAVI
This is a report on one patient with advanced kidney disease. The patient had fluid build-up after a heart procedure. It describes a rare case. There are no new results or large...
0055Prevalence of Endogenous Hypercortisolism in Individuals With Resistant Hypertension Stratified by Kidney Function: Results From the MOMENTUM Study
This study looked at people with hard-to-control high blood pressure. It checked if high stress hormone levels were linked to kidney function. It found that 27.3% had high stress...
Celastrol in kidney diseases: From therapeutic duality and toxicity to precision renal targeting
This review looks at a plant-based compound called celastrol. It shows how this compound protects kidneys in animal models. It is not tested in people yet. It could lead to new...
Risk Factors and Short-Term Outcomes of Lower Limb Fractures in Diabetic Patients Presenting to Emergency
This study looked at 180 people with diabetes who broke a bone in their leg or arm. It found that diabetes can make healing harder after a break. This is an observational study, so...
Disulfiram Attenuates Adenine‐Induced Renal Fibrosis by Modulating Inflammatory and Immunometabolic Responses
Researchers tested a drug called disulfiram in animals with kidney damage. The drug reduced scarring and inflammation in the kidneys. This was done in a lab setting, not in people...
Clinical and Medication-Related Factors Associated with Adverse Renal Outcomes in Advanced Chronic Kidney Disease Patients Treated with Empagliflozin: A Real-World Study in Thailand
This study followed people with advanced kidney disease who started taking empagliflozin. It looked at who had bad kidney outcomes after starting the drug. It is an observational...
0077Aromatase Inhibitors Versus Tamoxifen and Cardiovascular-Kidney-Metabolic Stage Progression in Women with Breast Cancer: A Real-World Database Propensity-Matched Cohort Study
This study compared two breast cancer drugs in women. It looked at how they affect heart and kidney health over five years. It is an observational study, so it shows a link, not...
Salt Intake and Kidney Outcomes in Older Adults With Chronic Kidney Disease: A Stage-Specific Cohort Study.
This study looked at older adults, age 75 and up, with kidney disease. It checked how much salt they ate and how their kidneys did over time. It is an observational study, so it...
Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial.
This is a plan for a new trial called THINK. It will test if adding a diuretic, or water pill, is the best next step for people with kidney disease and high blood pressure. There...
Pharmacological intersections between type 2 diabetes and cancer: metabolic crosstalk, antidiabetic therapies, and clinical implications.
This is a review article that summarizes what is known about the link between type 2 diabetes and cancer. It looks at how diabetes drugs might affect cancer risk. It does not...
Diabetes progression and severe hypoglycemia: a nationwide cohort study of 2,475,605 adults with type 2 diabetes mellitus.
This large study followed 2,475,605 adults with type 2 diabetes. It found that people with more severe diabetes, including those with kidney disease, were more likely to have very...
Targeting phospholipase Pla2g15 reduces long-chain BMP phospholipids abundance and senescence in kidney cells.
This study looked at kidney cells in the lab. It found that a specific enzyme helps cause cell aging and scarring in the kidney. This was done in cells, not in people yet. It...
Selective glomerular hypofiltration syndrome: a novel renal phenotype associated with cardiovascular disease and adverse outcomes in diabetic kidney disease.
Researchers studied 182 people with biopsy-proven diabetic kidney disease. They found a link between a specific kidney filter pattern and heart disease. This study shows a...
Dietary macronutrient intake and kidney outcomes in patients with type 2 diabetes: a cross-sectional study.
Researchers asked 472 people with type 2 diabetes in Tehran, Iran what they eat, using a detailed food questionnaire. They then compared how much protein, fat and carbohydrate...
Development and preliminary psychometric evaluation of the hemodialysis patient care dependency scale (HD-CDS).
Researchers built a new questionnaire to measure how much help people on hemodialysis (blood-cleaning treatment by machine) need with daily care. Until now, the questionnaires used...
Visceral Adiposity and Renal Health: From Pathophysiological Mechanisms to Novel Therapeutic Strategies
This review article looks at how visceral fat, the deep belly fat around the organs, may harm the kidneys, and at new treatments aimed at it. It summarizes earlier research and has...
Acute Kidney Injury or Physiological Response? Interpretation of Serum Creatinine Elevation After Strenuous Exercise Using Functional and Structural Kidney Biomarkers: A Narrative Review
This review discusses why creatinine levels often rise after hard exercise. It explains that this rise is usually a normal body response, not kidney damage. The article summarizes...
Impact of incremental peritoneal dialysis on long-term nutritional trajectories in end-stage kidney disease: a longitudinal cohort study
This study followed people on peritoneal dialysis to see how their nutrition changed over time. It looked at a specific dialysis method called incremental peritoneal dialysis. This...
Age- and sex-specific associations of underweight and excess adiposity with incident CKD in type 2 diabetes: nationwide Korean cohort study
This study looked at 1,824,317 adults with type 2 diabetes in Korea. It found that being underweight or having too much body fat raises the risk of developing kidney disease. The...
Heat shock proteins as modulators of cardiovascular health and disease: From cellular stress to clinical targets.
This review looks at how heat shock proteins help cells survive stress. It covers how these proteins affect the heart, blood vessels, and kidneys. The article summarizes past...
Wound healing, limb salvage and mortality after limb-salvage treatment in patients with diabetes and end-stage renal disease with limb-threatening ischemia: a systematic review and single-arm meta-analysis
This preprint is a meta-analysis that pools data from many studies on wound healing in people with diabetes and end-stage kidney disease. It looks at how well wounds heal after...
Diagnostic accuracy of AI-augmented renal ultrasound for degenerative kidney disorders: a systematic review and meta-analysis.
This review looked at 18 studies and found AI added to kidney ultrasound correctly identified degenerative kidney disease in most cases — about 85% accurate for detecting scarring...
Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts
This study looked at how kidney scarring happens in cells and animals. It found that a specific protein helps activate a signal that drives scarring. This work was done in the lab,...
Transdermal Creatinine Sensing in Live Animals with an Integrated Electrochemical Microneedle Patch
Researchers built a small patch that can check kidney levels in the fluid under the skin. It uses tiny needles to sample fluid without a blood draw. This test was done in live...
Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachment.
This study used tiny, lab-grown kidney models called organoids. It showed that high sugar levels cause inflammation and cell damage in these models. This was done in the lab, not...
Speckle Tracking Analysis of the Left and Right Heart in Type 1 Diabetes Patients with End-Stage Renal Disease Awaiting Simultaneous Pancreas-Kidney Transplantation
This preprint looked at heart scans of 16 people with type 1 diabetes and end-stage kidney disease. They were waiting for a combined pancreas and kidney transplant. It is a small...
Growth and development following paediatric kidney transplantation: Mechanisms, influencing factors, and clinical management.
This review explains how children grow after getting a kidney transplant. It covers factors like nutrition and growth hormone. It is a summary of known medical facts, not a new...
C-Reactive Protein as a Biomarker of Inflammation and Graft Injury After Kidney and Heart Allo- and Xenotransplantation Into Non-Human Primates.
Researchers tested whether C-reactive protein (CRP), a common blood marker of inflammation, can signal when a transplanted organ is being rejected. They studied 42 baboons and...
Knowledge Gaps and Educational Needs in Organ Donation: A Cross-Sectional Study Among Patients With End-Stage Renal Disease and Their Families.
Researchers gave questionnaires to people with kidney failure, also called end-stage renal disease (ESRD), and to their family members. The study ran at 2 large hospitals from...
Influence of Donor Age on Graft and Patient Outcomes in Kidney Transplantation: A Systematic Review and Meta-Analysis.
This study pooled earlier research to ask whether an older kidney donor means a worse result for the person who gets the kidney. The authors followed standard review rules (PRISMA...
Beyond the gift: unveiling the impact of donor-recipient relationship on donors’ quality of life and mental health – results of a european bi-center study
This study, run at 2 centers in Europe, looked at people who gave a kidney to someone while alive. It asked whether their relationship to the person who got the kidney, such as...
What People on Dialysis Say About Phosphorus and Kidney Transplantation
The National Kidney Foundation asked people on dialysis how they manage phosphorus, a mineral that builds up in the blood when kidneys fail. It also asked whether their care team...
Frailty assessed using the Edmonton Frail Scale predicts mortality and waitlist removal for kidney transplant candidates: a prospective study
This study followed 279 people waiting for a kidney transplant. It found that a frailty score could predict who was at higher risk of dying or being removed from the list. This is...
Women's Kidney Health in Focus: A Scientific Statement From the American Heart Association.
This statement from the American Heart Association highlights a gap in kidney care. Women are often left out of clinical trials, even though they have kidney disease. It calls for...
Chronic kidney disease prevalence in the Gulf Cooperation Council countries
This paper looks at how common chronic kidney disease is in the Gulf countries: Saudi Arabia, the UAE, Kuwait, Qatar, Bahrain and Oman. Studies of how common a disease is can show...
Artificial Intelligence- Assisted Dosing Optimization in Renal Impairment Patients: A Retrospective Observational Study
This study checked if AI tools can help doctors pick the right drug doses for people with kidney disease. It is a retrospective observational study, meaning it looks back at past...
From Metabolism to Molecular Phenotype: Carbonic Anhydrase IX–Targeted [ 68 Ga]Ga-DPI-4452 PET/CT in Renal Cell Carcinoma: A Prospective Multicenter Comparison with [ 18 F]FDG PET/CT
This trial compared two types of PET scans for kidney cancer in 68 people. It is a small randomized trial, so the results are promising but not definitive. The study looked at how...
Contemporary anticoagulation management across the spectrum of kidney disease: a narrative review and expert Recommendations by Kasralainy Nephrology Group (KANG)
This review gives expert advice on blood thinners for people with kidney disease. It summarizes what is known but does not report new trial results. It helps doctors balance the...
Ultrasonic-With-Ballistic Versus Pneumatic Lithotripsy in Percutaneous Nephrolithotomy for 2-4 cm Renal Calculi: A Prospective Quasi-experimental Comparative Study in a Bangladeshi Tertiary-Care Hospital
This study compares two methods for breaking up kidney stones. It is a comparative study, but the abstract is missing. We do not have the full results to grade it. It likely helps...
Beyond procedure counts: reconsidering physician involvement in maintenance hemodialysis
This article discusses how doctors should be involved in dialysis care. It is an opinion piece, not a study with results. It argues for more doctor involvement in dialysis. It...
Successful hemodialysis withdrawal with glucocorticoid treatment after achieving infection control in a case of crescentic IgA-dominant staphylococcus-associated glomerulonephritis
This is a case report about one 70-year-old woman with a rare kidney infection. It describes how she recovered enough to stop dialysis. It is a single patient story, not a study...
Multisystem involvement associated with AL-amyloidosis: A clinical case
This report tells the story of one patient with long-standing kidney disease. Doctors found a rare protein buildup in the heart and other organs. This condition is called...
Biomarkers in Clear Cell Renal Cell Carcinoma: From Biological Association to Clinical Decision-Making
This review discusses how doctors can use blood tests and scans to choose the best treatment for kidney cancer. It summarizes existing evidence but does not report new trial...
Case Report: Concurrent Fabry disease, IgA nephropathy and undifferentiated connective tissue disease in a female with normal enzyme activity
This report describes a woman who had three rare conditions at the same time. It highlights how hard it can be to diagnose these diseases when standard tests look normal. This is a...
Intracranial Phosphaturic Mesenchymal Tumor Mimicking Meningioma and Causing Tumor-Induced Osteomalacia: A Case Report
This report describes a woman with a brain tumor that caused her kidneys to waste phosphate. This led to weak bones and muscle pain. It is a single case report, so it does not...
Validity of EHR-Derived Phenotypes for Outcome Ascertainment in the PRESERVE Trial: Implications for Embedding RCTs in Healthcare Systems
This paper checks if hospital computer records can track study results as well as a research team can. It uses data from a kidney protection trial. It is about how to run studies,...
Case Report: Long-standing multisystem Wilson's disease in a pregnant woman with prolonged chelation discontinuation
This is a story about one pregnant woman with a rare copper disorder. She stopped her medicine for over a year before getting pregnant. It is a single case, not a study with...
Precision medicine in pediatric sepsis-associated acute kidney injury: when systemic heterogeneity meets organ-level heterogeneity
This article discusses how to treat kidney injury in children with sepsis. It looks at how different bodies react to the same illness. There are no new results in this piece. It is...
Integrating non-communicable disease screening to COVID-19 and human immunodeficiency virus care in Johannesburg South Africa: a pilot model for low- and middle-income countries
This study tested a way to check for chronic diseases in HIV clinics. It involved 461 people in South Africa. It shows that adding these checks can work in busy clinics. It is a...