← brief for 2026-09-17 · Regeneration & devices

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts

Article D Peer reviewed Preclinical

Key takeaways

This study looked at how kidney scarring happens in cells and animals. It found that a specific protein helps activate a signal that drives scarring. This work was done in the lab, not in people yet, so it is a step toward future treatments.

Who did this work

Yu Chen (Southern Medical University) · Weiwei Xu (Southern Medical University) · Jieli Yu (Southern Medical University) · Pei Deng (Southern Medical University) · Nianping Liu (University of Science and Technology of China) · Yinyin Li (Southern Medical University) · Hui Zhou (Southern Medical University) · Hong Zhou (Southern Medical University) · Jianchuan Wang (Sun Yat-sen University) · Bo Zhao (Sun Yat-sen University) · Florian Winau (Harvard University) · Fan Fan Hou (Southern Medical University)

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-17
https://doi.org/10.1172/jci.insight.203039