← brief for 2026-09-17 · Slowing decline

Targeting phospholipase Pla2g15 reduces long-chain BMP phospholipids abundance and senescence in kidney cells.

Article D Peer reviewed Preclinical

Key takeaways

This study looked at kidney cells in the lab. It found that a specific enzyme helps cause cell aging and scarring in the kidney. This was done in cells, not in people yet. It points to a possible new target for drugs that could slow kidney decline.

Who did this work

Rijt SV · Denis SW · Butter LM · Schomakers BV · Ofman R · Weeghel MV · Vaz FM · Dane AD · Piersma SR · Jimenez CR · Florquin S · Gao AW

Source

Article · PubMed, CKD progression and prevention · 2026 Sep 16
https://pubmed.ncbi.nlm.nih.gov/42754265/