Kidney research, 2026-09-10
Today brought no new kidney research, so the day is one for steady habits
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One animal study reported a Chinese herbal formula slowing muscle loss in rats, which is far too early to mean anything for people.
Some days the research world simply does not produce kidney news, and this is one of them. The closest item is a review weighing three eating patterns for people living with both obesity and kidney disease, and it leans toward whole patterns you can actually stick with rather than strict single-nutrient rules. Everything else that came in studied other conditions, or studied animals, so it cannot be stretched to cover kidneys. A quiet day is a reasonable time to check in with your care team about the plan you already have.
Cumulative metabolic burden and urinary albumin-to-creatinine ratio in non-diabetic adults: a nationwide population-based study.
This nationwide study looked at adults without diabetes and asked whether piling up metabolic problems over time tracks with early kidney damage. The damage marker is albumin in...
Epidemiology, Risk Factors and Outcomes of AKI and CRRT in Patients on ECMO: Workgroup Statements from the Joint Acute Disease Quality Initiative (ADQI) and Extracorporeal Life Support Organization (ELSO) Consensus Conference on ECMO, AKI, fluid management and CRRT.
This is a consensus statement from two expert groups about sudden kidney injury in patients on ECMO, a machine that takes over for failing heart or lungs. They report that 40 to 80...
Association of neutrophil-to-lymphocyte-platelet ratio with residual renal function in early-stage peritoneal dialysis patients.
This study tested a blood measure that combines three cell counts: neutrophils, lymphocytes and platelets. In people on peritoneal dialysis, a home form of dialysis, a higher...
Sex differences in cardiac function and remodelling in patients with preserved left ventricular ejection fraction across all stages of chronic kidney disease.
Doctors reviewed heart scans from 84 people with kidney disease across all five stages, matched for sex, plus healthy people for comparison. Everyone had normal heart pumping...
Efficacy of desmopressin in reducing post-procedural bleeding among chronic kidney disease patients: a systematic review and meta-analysis.
Researchers pooled results from randomized trials, searching three medical databases through August 2025, to test whether the drug desmopressin cuts bleeding when people with...
Renal Safety of Intravitreal Ranibizumab and the Effects of SGLT2 Inhibition in Diabetic Macular Oedema: A Post Hoc Analysis of the COMET Trial.
This is a follow-up look at 53 people from the COMET randomized trial, all with swelling in the back of the eye from diabetes. Researchers checked whether eye injections of the...
[Blood pressure effects of potent GLP-1 and GIP analogues].
This is a review article about strong weight-loss drugs in the GLP-1 and GIP families, written to explain their effect on blood pressure. The authors report that these drugs lower...
Finerenone Use in Heart Failure Patients with Type 2 Diabetes and Kidney Disease: An Analysis of the FINE-TURK Registry.
Doctors in Turkey reviewed records from the FINE-TURK registry to see how the drug finerenone performed in people who have type 2 diabetes, kidney disease and heart failure all at...
Discovery of a Covalent NLRP3 LRR-Domain Probe: Reversing Renal Fibrosis via Immunometabolic Reprogramming in Organoid and Murine Models.
Scientists built a new lab compound called QX-31 that shuts off NLRP3, a protein switch that drives inflammation and kidney scarring. It works by locking onto a specific spot on...
Profile, follow-up adherence and progression of people with advanced chronic kidney disease in specialized care centers: a retrospective study, Santa Catarina state, Brazil, 2021-2024.
Researchers looked back at medical records from five kidney clinics in Santa Catarina, Brazil, covering people treated between November 2021 and October 2024. Everyone had stage 4...
ISN North & East Asia Regional Board Webinar: Rethinking CKD screening: global perspectives on early detection and timely intervention - International Society of Nephrology
This is an online talk scheduled for October 13, 2026, hosted by the International Society of Nephrology. Experts will discuss why chronic kidney disease is often found too late,...
Gut Microbiota and Their Metabolites in Acute Kidney Injury: Classification, Mechanisms, and Therapeutic Potential
This review sorts through what gut bacteria and the chemicals they make do during sudden kidney injury, which is a fast drop in kidney function rather than the slow kind. It...
Reciprocal mediation of immuno-inflammation and insulin resistance in the risk of chronic kidney disease among patients with coronary artery disease: insights from neutrophil-to-lymphocyte ratio and triglyceride-glucose index
In people with clogged heart arteries, researchers checked two cheap blood markers: one for inflammation, based on the ratio of two white blood cell types, and one for insulin...
Birth characteristics and growth outcome in children with nephropathic cystinosis compared with other chronic kidney disease entities prior to kidney replacement therapy
Researchers compared birth size and later growth in children with nephropathic cystinosis, a rare inherited disease that damages the kidneys, against children with other kinds of...
Random Urinary Calcium/Creatinine Ratio as a Predictor of Dehydration in Hypercalcemic and Normocalcemic Patients
This study tested whether one urine sample, comparing calcium against creatinine, can flag dehydration. Creatinine is a waste product used to judge how concentrated the urine is....
Cardio-Renal Interaction Between NT-proBNP and Renal Function Across Chronic Kidney Disease Stages in Patients with Heart Failure
This study looked at NT-proBNP, a blood marker of heart strain, in people with heart failure at different stages of kidney disease. Weak kidneys raise this marker on their own,...
SGLT2 Inhibitors in Nephrolithiasis: Emerging Evidence and What Urologists Need to Know
This review pulls together what is known about SGLT2 inhibitors and kidney stones. SGLT2 inhibitors are diabetes drugs that also slow kidney decline. The evidence so far comes from...
Comprehensive Haematological Alterations in Chronic Kidney Disease: Pathophysiological Mechanisms and Clinical Implications in Patients Attending Private Hospitals in Baghdad
Doctors in Baghdad looked at blood test changes in people with chronic kidney disease at private hospitals. Kidney disease often lowers red blood cells, which causes tiredness and...
A comparative real-world analysis of finerenone and steroidal mineralocorticoid receptor antagonists in patients with chronic kidney disease
This study compares finerenone, a newer kidney and heart drug, with older drugs in the same family such as spironolactone. It uses real-world records of people with chronic kidney...
Vasculitis Syndromes with Renal Involvement: A Review from a Case Series.
This review explains vasculitis, which is inflammation of blood vessels, when it attacks the kidneys, using real patient cases. Two forms, microscopic polyangiitis and...
Pharmacological inhibition of endoplasmic reticulum stress ameliorates polystyrene nanoplastic-induced renal injury in female Wistar rats.
Tiny plastic particles, called nanoplastics, were given to rats to damage their kidneys on purpose. The researchers then tested a drug, 4-PBA, that calms a stress response inside...
Abdominal aortic calcification index and prognosis in patients with chronic kidney disease: a meta-analysis
This review pooled many earlier studies that scored calcium buildup in the main artery of the belly on scans in people with kidney disease. It asked whether a higher score goes...
Plasma neurofilament light chain in type 2 diabetes: Associations with diabetic peripheral neuropathy, age, and renal function in a pilot cross-sectional study
This small study measured a blood marker of nerve damage, called neurofilament light chain, in people with type 2 diabetes. It checked whether the marker tracks with nerve damage...
Addressing the Pathophysiology of Venous Thrombosis and Chronic Kidney Disease in Sickle Cell Trait Using a Mouse Model
Researchers built a mouse model to study why sickle cell trait is tied to blood clots in veins and to long-term kidney damage. Sickle cell trait means carrying one copy of the...
Chronic obstructive pyelonephritis - Female, 71 - Tissue image [6270730022336411]
This is a stored tissue image from a 71-year-old woman with a long-running kidney infection that blocked urine flow. It is a picture filed for teaching and research, not a study....
Personalized Sequential Nephron Blockade for Diuretic Resistance in Acute Decompensated Heart Failure: A Narrative Review for the Cardiorenal Clinician
Doctors wrote a guide on what to do when one water pill stops clearing fluid in people with heart failure. The idea is to use several drugs together, each one blocking salt and...
Clinical characteristics and prognosis of IgA nephropathy and comorbid diabetic kidney disease
This study looked at people who have two kidney diseases at once: IgA nephropathy and diabetic kidney disease. IgA nephropathy is when the immune system damages the kidney's tiny...
Latent histopathological activation of the renin–angiotensin–aldosterone system in children with low birth weight
Researchers examined kidney tissue from children who were born small, at a low birth weight. They found quiet signs that the hormone system controlling blood pressure and salt,...
Effect of Empagliflozin in Patients With eGFR Between 10 and 20 ml/Min/1.73m2
This trial tests empagliflozin, a diabetes drug that also protects kidneys, in people whose kidneys are barely working. Their kidney filtering rate (eGFR) is between 10 and 20,...
FGF23 regulates phosphate and vitamin D metabolism during acute kidney injury and recovery.
When the kidneys are suddenly injured, a hormone called FGF23 shoots up fast. FGF23 controls how the body handles phosphate, a mineral, and vitamin D. Researchers tracked that...
Renaclic for Chronic Kidney Disease Self-Management: Formative User-Centered Co-Design Study.
Researchers describe how they designed Renaclic, a digital tool to help people manage kidney disease day to day. They built it together with patients and health care staff, aiming...
Epidemiology And Multimorbidity Burden Of Arthritis Among Elderly Patients: A Hospital-Based Cross-Sectional Study In South India
This hospital record posted to an open repository counts how common arthritis is among older patients in South India and what other illnesses they carry alongside it. Patients were...
Clinical, Social, and Healthcare Factors Associated with Nutritional Status in Amyotrophic Lateral Sclerosis: A Multidimensional Approach.
Researchers checked the nutrition of 97 adults with ALS, a disease that slowly weakens the muscles, at one point in time. They looked for which clinical, social, and care-system...
Effects of Brussels Chicory and Concurrent Exercise Training on HDL Function and Subclass Profiles in Overweight College Students: A Pilot Randomized Controlled Trial.
This was a small pilot study in overweight college students who were split at random into three groups. One group took a supplement made from Brussels chicory, a leafy vegetable...
Beyond Bone Health: Exploring the "Heart-Brain-Bone" Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2).
This is a review article that proposes a way of thinking, not a study with results. The authors argue that heart disease, memory loss, and thinning bones share common causes, such...
The Circadian System and Chronic Kidney Disease Risk: Epidemiological Evidence.
About 10% of people worldwide have chronic kidney disease. This review gathers past studies on whether a disturbed body clock raises that risk, looking at night shift work,...
Development and preliminary psychometric evaluation of an oral health questionnaire for chronic kidney disease (CKD-OHQ)
Researchers built a questionnaire that asks people with kidney disease about their teeth, gums, and mouth problems. They gave it to a first group of patients to see if the...
Oral beta-D-glucan challenge to assess gut permeability in subjects receiving haemodialysis
People on dialysis drank a sugar from yeast cell walls, beta-D-glucan, to test whether their gut lining leaks. If the sugar shows up in the blood, the gut wall is letting things...
Alterations in physical performance and body composition in non-dialysis chronic kidney disease detected by a comprehensive multidimensional analysis
Researchers measured strength, movement, and body makeup in people with kidney disease who are not on dialysis. They looked at several measures together instead of one at a time,...
Inspiratory Muscle Training During Hemodialysis
This trial tests training the breathing muscles during dialysis sessions in adults on regular hemodialysis. Everyone spends 12 weeks with no study training first. Then people are...
Remotely Delivered Nutrition Interventions with or Without Physical Activity Interventions in Adults with Cardiovascular Diseases: A Systematic Review of Randomized Controlled Trials.
This review pulled together randomized trials of diet coaching delivered at a distance, by phone or app, for adults with heart disease. Some trials added exercise coaching on top....
Association of Domain-Specific Physical Activity with Sleep Disorders in U.S. Adults: A Cross-Sectional Study Based on NHANES.
This study looked at 25,732 American adults, average age about 50, in a national health survey. It compared sleep problems against activity at work, activity while getting around,...
Sanhua Tea Alleviates Obesity Symptoms by Improving Blood Lipid Levels, Gut Microbiota, and Liver Metabolome in Mice.
Mice fed a high-fat diet were given Sanhua tea, a blend of rose, jasmine, bitter orange, lotus and a Chinese herb. The tea improved their blood fat levels and changed their gut...
Beyond Composition: Processing-Driven Transformations and Functional Trade-Offs of Matcha Tea in Foods.
This review describes what happens to matcha green tea powder when it is cooked into other foods. It covers how heat and food mixing change the active plant compounds and how well...
Exercise and Brain Health in Postmenopausal Women: A Review of Cognitive Benefits, Mechanisms, and Neurodegeneration Prevention.
This review summarizes why exercise may protect thinking skills in women after menopause. It describes the hormone, blood flow and inflammation changes that happen at menopause....
Exploring the Role of Resistance Training in the Prevention and Management of Chronic Conditions: A Narrative Review.
This is a broad overview arguing that strength training deserves more attention than it gets next to walking and other aerobic exercise. It discusses muscle strength, staying...
Dietary Patterns for Obesity in CKD: Mediterranean, Low-Carbohydrate, and Plant-Forward Approaches-What Fits Best?
This review compares three ways of eating for people who have both obesity and kidney disease: the Mediterranean diet, mostly-plant diets, and low-carb or keto diets. Extra weight...
Shenshuai Yingyang Jiaonang attenuates CKD-induced muscle atrophy: a role for Faecalibacterium prausnitzii and the EGFR/PI3K/AKT signaling axis.
Muscle wasting is common in kidney disease and there is no good treatment for it. This study tested a traditional Chinese herbal formula, Shenshuai Yingyang Jiaonang, in animals...
Associations Among Caregiver Burden, Mindful Self-Care, and Health Perception in Informal Caregivers of Patients With Chronic Kidney Disease: A Cross-Sectional Study.
This study surveyed unpaid family caregivers of people with chronic kidney disease at a single point in time. It measured how heavy the caregiving load felt, how healthy caregivers...
Brain health strategies in middle-aged individuals with mild neurocognitive disorder: a scoping review.
This is a broad survey of the published literature, not a study of people. It looks at what middle-aged adults with mild thinking and memory problems are advised to do to protect...
Prevalence of dementia and BPSD in community-dwelling older adults with advanced care needs: a nationwide survey in Taiwan.
This national survey in Taiwan covered 11,297 older adults who need heavy day-to-day care, including some on dialysis. It counted how many had dementia and how many had the...
Network analysis of mental health literacy and depressive/anxiety symptoms in patients under maintenance hemodialysis: a cross-sectional study of multicenter data.
Researchers surveyed 757 people on long-term dialysis at 6 hospitals in Sichuan, China. They measured depression, anxiety, and how well people understand mental health, then mapped...
eNOS Uncoupling, Shear-Stress Tolerance, and the Two-Threshold Model of Post-Exertional Malaise in Long COVID: A Mechanistic Hypothesis With Implications for Physiotherapy and Recovery Protocols.
This paper puts forward an idea to be tested, not a study with data. The authors propose that in some people with long COVID, the crash that follows exertion comes from a fault in...
Sleep Quality and Falls Risk in the ELSA Study: A Cross-Sectional and Prospective Cohort Study.
Using data from a long-running English study of adults aged 50 and over, researchers compared sleep quality with the risk of falling. They looked both at one moment in time and at...
Long COVID-19 in Spain: A Phenomenological Exploration of Health, Support, and Systemic Challenges.
This study interviewed 36 people in Spain who live with long COVID, across 17 provinces over 10 months. It is a listening study: it reports what people said about their health, the...
The Effects of Guided Imagery on Women's Health: A Systematic Review of Experimental Studies.
This review gathered experimental studies of guided imagery in women, a relaxation practice that uses vivid mental pictures. It looked at cancer care, pregnancy, childbirth and...
Spiritual Well-Being as a Patient-Reported Assessment Dimension in Advanced Cancer: Clinical Validation and Quality-of-Life Implications.
Researchers tested a questionnaire that measures spiritual well-being in people with advanced cancer. They found that scores on it lined up with quality of life scores. This shows...
A Mobile Application Intervention for Emotional Health in Older Adults: Designed for Dementia Prevention.
Adults aged 60 and over, none of whom had dementia, used a phone app called MELI built to protect thinking skills. Researchers measured depression, anxiety and life satisfaction...
Biomolecular Pathways Linking Preoperative Chronic Stress to Postoperative Cardiovascular Dysfunction in Noncardiac Surgery.
This is a discussion paper arguing that long-term stress before surgery may raise the odds of heart trouble afterward. It walks through the body pathways that could explain it,...
Hemoadsorption/Hemodialysis: Current Evidence and Outcome on Uremic Toxin Removal and Symptom Improvement.
This review looks at adding hemoadsorption to dialysis, which means passing blood over a material that soaks up toxins. People on dialysis often still feel unwell because some...
Vitamin E-Coated Super High-Flux Membranes: Toward Enhanced Middle Molecule Removal and Improved Biocompatibility.
This review covers new dialysis filters coated with vitamin E, designed to remove larger waste molecules and be gentler on the blood. In kidney failure, toxins build up and drive...
On-Line High-Volume Hemodiafiltration: Current Evidence and Clinical Outcomes.
This is a review article about a dialysis method called on-line high-volume hemodiafiltration, or OL-HDF. Regular dialysis clears small waste well but leaves behind bigger "middle...
Mechanisms of regeneration and maladaptive repair in acute kidney injury
This is a review article about how kidneys heal after a sudden injury. It lays out why that repair sometimes goes wrong and leaves scarring that becomes long-term kidney disease....
Continuous biosensing and real-time metabolic monitoring in obesity, diabetes, and diabetic kidney disease: implications for precision diabetes and kidney care
This review covers wearable sensors that track blood sugar and other body chemistry continuously in people with obesity, diabetes and diabetic kidney disease. The authors argue...
Prednisolone-Induced Acneiform Eruption with Facial Flushing in A Kidney Transplant Recipient: A Probable Adverse Drug Reaction
A kidney transplant patient developed an acne-like rash and facial flushing after taking prednisolone, a steroid used to stop the body rejecting the new kidney. This is a report on...
Supraceliac Aortobifemoral Bypass for Live Donor Renal Transplant
Surgeons describe one patient whose main blood vessels were too diseased to accept a kidney from a living donor the usual way. They built a bypass from the upper part of the aorta,...
Florida Health and Health Care: A Status Report.
This report compares Florida's health and health care with national numbers, covering fast population growth, gaps in insurance, thin public health funding, and a large share of...
IV DrugRef PWA
This is a released app for looking up how to give drugs through an IV line. It is a software posting, not research, and it is not about kidney disease. There are no results of any...
Hearing impairment among haemodialysis patients with chronic kidney disease: a South African perspective
This paper raises hearing loss as a problem for South Africans on dialysis for kidney failure. It is written as a perspective on the issue in one country, looking at who is...
Understanding variation between kidney centres in implementation of tolvaptan in the management of autosomal dominant polycystic kidney disease: a multiple case study
Kidney centres do not all use tolvaptan the same way. Tolvaptan is a drug that slows cyst growth in polycystic kidney disease, an inherited condition that damages the kidneys over...
Urinary albumin fraction and tubulointerstitial injury: an association shaped by diagnostic composition
This study looked at what share of the protein in urine is albumin, and whether that share tracks damage to the kidney's tubes and surrounding tissue. The authors found the link...
Explainable Machine Learning for Chronic Kidney Disease Classification from Routine Urinalysis and Diabetes Records
Researchers built a computer model that flags chronic kidney disease using routine urine tests and diabetes records. The model is designed to show which factors drove each...
Prevalence of chronic kidney disease in rheumatoid arthritis and implications for the use of DMARDs – an in-hospital analysis
Researchers counted how many hospital patients with rheumatoid arthritis also had chronic kidney disease, and what that meant for their arthritis drugs. Several of those drugs are...
Adequacy of dialysis in children and adolescents: more than just Kt/V
This is a review article arguing that judging dialysis in children takes more than one number. That number, Kt/V, measures how much waste a session clears from the blood. The...
Economic Development and Chronic Kidney Disease Prevalence: Evidence of Nonlinearity from a Global Panel, 1995–2023
Researchers compared how rich countries are with how common kidney disease is there, using data from many countries between 1995 and 2023. The link is not a straight line: the rate...
Diabetes, chronic kidney disease, and annual hospital costs in older patients: A cost decomposition analysis
This study measured what hospital care costs each year for older patients who have both diabetes and kidney disease. It breaks the total down to show which parts of care drive the...
CKD Specific Telemonitoring Platform to Minimize Adverse Outcomes in High Risk CKD Patients
Doctors are testing a virtual care platform called VIEWER for people with kidney disease who are at high risk. They want to know if adding it to normal care cuts emergency room...