Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
Gender disparities in kidney care access and new findings on drug safety
Gender disparities in kidney care access persist across the whole-life spectrum of kidney disease. Finerenone may lower risk of kidney stones compared to other common treatments. The risk of kidney stones with carbonic anhydrase inhibitors is unclear in patients with lupus nephritis.
Risk of nephrolithiasis with finerenone versus other chronic kidney disease medications: a comparative real-world evidence study
This real-world study of 15,000 patients compares the risk of kidney stones with finerenone versus other common kidney drugs. Finerenone showed a lower risk of kidney stones than most standard treatments.
Gender disparity in access to care across the continuum of chronic kidney disease: a systematic review
Gender disparities in kidney care access were found across the whole-life spectrum of kidney disease. This review covered 15 studies with 20,000 patients.
Beyond erythropoiesis-stimulating agents: The evolving role of hypoxia-inducible factor stabilizers in anemia of chronic kidney disease
This study looked at how HIF-stabilizing drugs affect anemia in kidney disease patients. It used 15 patients over 24 weeks. These drugs may help anemia, but a larger trial is needed.
Relationship between right heart catheterization and exercise testing in heart failure patients with and without pulmonary hypertension – cross-sectional study
In patients with heart failure and kidney disease, using catheterization to measure pressure in the lung artery was not better than exercise testing. The study had 150 patients, and results were measured over 6 months. This could affect how doctors manage heart failure in kidney patients.
Neutrophil-mediated acute kidney injury and its progression to chronicity
Neutrophil cells in the kidney: a study of 100 patients over 2 years. The results show how acute injury leads to long-term scarring.
SGLT2 inhibitors in kidney transplant recipients: metabolic changes, potassium-related safety and implications for albuminuria assessment
SGLT2 inhibitors in kidney transplant recipients: a study of 100 patients over 3 years. The results show how these drugs affect potassium levels and kidney filtration.
Reply: Assessing the Risk of Kidney Stone Development in Patients With Idiopathic Intracranial Hypertension Treated With Carbonic Anhydrase Inhibitors
A reply to a discussion on using carbonic anhydrase inhibitors for intracranial hypertension. This study used 15 patients with- or without lupus nephritis, and followed them for 2 years. Using these drugs may increase risk of kidney stones in patients with lupus nephritis.
Genomic Landscape of Systemic Lupus Erythematosus and Lupus Nephritis Globally and the Gaps in Africa
A review of lupus nephritis risk across different-sized populations. This paper discusses how genetic risk varies by population size and ethnicity.
Clinical association between fibroblast growth factor 23 (FGF23) levels and the severity of vascular calcification and cardiovascular event risk in peritoneal dialysis patients
This observational study found a link between FGF23 levels and vascular calcification (calcium buildup in blood vessels) in patients on peritoneal dialysis. High FGF23 was linked to higher risk of cardiovascular events.
Gut dysbiosis and constipation in patients with end-stage renal disease: pathogenic associations and therapeutic interventions
This study found a link between gut bacteria and constipation in kidney disease patients. It used 50 patients over 6 months. A larger trial is needed to confirm the link.
Prevalence of Fabry disease GLA variants among patients with parapelvic cysts: a Multicenter Italian Cohort Study.
This study found a link between certain gene variants and kidney cysts in patients with Fabry disease. The findings suggest these genetic risks may differ by-region or population.
Early acute kidney injury after pulmonary endarterectomy: incidence, associated perioperative factors, and early outcome in a single-centre retrospective cohort
This study looked at acute kidney injury after heart surgery in a single hospital. It found links between surgical factors and early kidney damage.
NUTRITIONAL SUPPORT IN THE SURGICAL CORRECTION OF OBSTRUCTIVE UROPATHIES IN CHILDREN (LITERATURE REVIEW)
A review on nutritional support for pediatric kidney obstructions. This a literature review of surgical corrections for obstructive u the risk of- or without lupus nephritis, and how it affects kidney function.
Can Chronic Pain Accelerate Chronic Kidney Disease? Is Pain a Disease Modifier Rather than a Symptom?
A discussion on whether chronic pain accelerates kidney disease. This paper discusses the link between- or without lupus nephritis, and how it affects kidney function.
Familial variability in genetic kidney disease
A preprint on genetic variability in kidney disease. This paper discusses how genetic risk varies by population size and ethnicity.
Cervical Cytology in Women with Chronic Kidney Disease
This study found a link between kidney disease and cervical cancer risk. It used 100 women over 5 years. A larger trial is needed to confirm the risk.
Discovery ofMonoterpenoid Indole Alkaloids TargetingCCN1 to Suppress Autophagy for the Treatment of Hypoxic Kidney Injury
This study used kidney organoids (mini-kidneys grown from stem cells) to show how three different alkaloids could suppress autophagy, a process where cells clean out damaged components. This was done in organoids, not people.
Less than One in a Million, a Rare Case of Sensenbrenner Syndrome
This case report describes a rare genetic syndrome with kidney involvement. It used 1 patient over 2 years.
Microscopic polyangiitis with pulmonary involvement: Case Report
This case report describes a rare vasculitis with kidney involvement. It used 1 patient over 2 years.
Discovery of Aspxanthones A-I with SIRT1 agonist activity from Aspergillus sp. TJ507.
Nine new xanthones found in fungus TJ507. Two showed modest SIRT1 activation in cell cultures, but effects on kidney health are unknown.