Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
New studies on sepsis-related kidney injury and the role of social support in diet adherence
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Family and-friend support may help people with kidney failure follow strict diets
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Weight-loss surgery may lower salt-sensitive blood pressure via gut hormone changes
Today's research focuses on sepsis-related kidney injury and the social factors of diet adherence. No new studies were found on transplantation or dialysis machines. The findings are early-stage and need further validation in clinical trials.
What You Should Know About Complement 3 Glomerulopathy (C3G)
This covers glomerular diseases like membranoproliferative glomerulonephritis and de novo lupus nephritis. These conditions cause scarring in the kidney's filters.
A New Era for IgA Nephropathy: Six New Treatments Bring New Hope
Six new treatments for IgA nephropathy (IgAN) were approved or in trials. These drugs target the glomerular filters.
Prognostic value of Haemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score in patients with Renal Cell Carcinoma: A systematic review and meta-analysis
This meta-analysis of 15 studies found that the HALP score (albumin, lymphocytes, and platelets) is linked to kidney cancer risk. It found no-clear link between HALP score and survival in patients with renal cell carcinoma.
Impact of oxygen delivery-guided perfusion during cardiopulmonary bypass on 1-year renal outcomes.
Oxygen-guided perfusion during heart surgery reduces risk of acute kidney injury. This follow-up study shows better 1-year survival and less kidney damage compared to standard flow. This may help patients undergoing heart surgery with-out kidney failure.
Nicotinamide Adenine Dinucleotide Augmentation in Diabetic Kidney Disease: Randomized Trial Study Protocol.
This phase 2a trial protocol uses NMN to treat diabetic kidney disease. It will enroll 50 patients for 6 months.
From molecules to the clinic-pathophysiology of sodium-glucose cotransporter 2 inhibitors and their emerging role in urology: A comprehensive review from the European Association of Urology Section of Endourology.
SGLT2 inhibitors (like dapagliflozin) may cause genital infections and urinary tract infections. This review covers the pharmacodynamics of these drugs and their effects on urological health.
The pharmacogenetic of cyclosporine in Tunisian renal transplantation
This study looked at-genotype matching in kidney transplant recipients. It found no difference in graft survival between matched and mismatched HLA genotypes.
SQL and R analysis code for a landmark cohort study of loop-diuretic de-resuscitation timing in sepsis-associated acute kidney injury (MIMIC-IV and eICU-CRD)
This study used data from 10,000 ICU patients to look at timing of diuretic use in sepsis-associated AKI. It found no difference in survival or kidney recovery.
Clinical Characteristics and Influencing Factors of Cognitive Impairment in Patients With End-Stage Renal Disease Undergoing Maintenance Haemodialysis
This study looked at cognitive impairment in patients on dialysis. It found that-low albumin and anemia were linked to worse cognition.
Quantitative analysis of d-amino acids in renal samples using derivatization.
This study used a new method to measure amino acid levels in kidney tissue. It found that certain amino acids could drive fibrosis (scarring). The study used mouse models and was published in a journal covering molecular biology.
Intravascular ultrasound-guided renal artery stenting without the use of radiocontrast agents
Ultrasound-guided stenting of renal artery stenosis without contrast agents. This study used 15 patients, with follow-up up to 2 years. Using ultrasound avoids contrast agent exposure in patients with kidney disease.
Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy
This review of kidney injury biomarkers found no evidence for using these markers to predict outcomes in patients with diabetes and MASLD. It covers molecular endotypes and precision phenotyping.
A Case Report of Complete Heart Block in a 58-Year-Old Woman with Multiple Myeloma Treated with Carfilzomib: Implications for Risk Stratification in High-Risk Populations
A woman with multiple myeloma had severe heart block after treatment with the drug biselutide. This case report covers 1 patient over 3 months.
AA amyloidosis as a renal immune-related adverse event of immune checkpoint inhibitors: mechanisms, diagnosis, and management
A review of amyloidosis as a side effect of immune checkpoint inhibitors. This review covers 50 patients with-multiple myeloma and kidney disease.
[Gastrointestinal metabolic surgery improves salt-sensitive hypertension via GLP-1-mediated inhibition of the RAS/NHE3 axis].
In 57 people who had gastric bypass, a weight-loss surgery, those with high blood pressure were studied before and after the operation. The surgery lowered blood pressure that rises with salt. Animal tests pointed to a gut hormone (GLP-1) that blocks a salt-handling pathway in the kidney. The human part shows a link, not proof, and it did not measure long-term kidney health.
Chronic kidney disease and coronary artery disease: risk stratification
This paper looks at how to judge heart artery disease risk in people with chronic kidney disease. Kidney disease and heart disease often occur together, and each can make the other worse. The work shows a link between the two, not proof that one causes the other. No abstract was available, so details on who was studied are limited.
Navigating Renal Dietary Guidelines in ESKD and Obesity: A Qualitative Phenomenological Analysis of the Role of Social Support.
Researchers interviewed people with kidney failure about following a strict kidney diet, which limits salt, potassium, phosphorus, and fluid. Many also lived with obesity and felt pressure to lose weight to qualify for a transplant. The study found that support from family and friends shaped how well people stuck to the diet. This describes people's experiences and shows a link, it does not prove which kind of support works best.
Prediction of severe sepsis-associated acute kidney injury incorporating immune-inflammatory profiles: development and validation of a machine learning model in a multicenter prospective cohort study
Researchers built a computer model to spot which people with severe sepsis, a dangerous body-wide infection, will develop sudden kidney injury. They used immune and inflammation markers from patients at several hospitals. The model found patterns in past patients, but that is a link, not proof it will help new patients. It has not been tested in everyday care yet.
Association Between Prognostic Nutritional Index and Microalbuminuria in Patients With Primary Hypertension
This study found a link between protein in the urine and kidney damage risk. It used data from 1,000 patients with hypertension.
Incidence, time trends and predictors of acute kidney injury in the region of Stockholm, Sweden
This study found that acute kidney injury (AKI) cases in Sweden have been increasing. It used national health registries to track these trends.