Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
New research on potassium, magnesium and calcium levels in kidney disease
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A study of 15 patients found potassium, magnesium and calcium levels are linked to kidney function
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A study of 100 patients found sepsis risk in kidney disease
Today's research focuses on electrolyte imbalances and sepsis risk in kidney disease. We cover a new trial protocol for NMN use in diabetic kidney disease. Other studies discuss cardiovascular risk and proteinuria markers.
Prognostic value of Haemoglobin–Albumin–Lymphocyte–Platelet (HALP) Score in patients with Renal Cell Carcinoma: A systematic review and meta-analysis
This meta-analysis of 15 studies found that the HALP score (albumin, lymphocytes, and platelets) is linked to kidney cancer risk. It found no-clear link between HALP score and survival in patients with renal cell carcinoma.
Impact of oxygen delivery-guided perfusion during cardiopulmonary bypass on 1-year renal outcomes.
Oxygen-guided perfusion during heart surgery reduces risk of acute kidney injury. This follow-up study shows better 1-year survival and less kidney damage compared to standard flow. This may help patients undergoing heart surgery with-out kidney failure.
Nicotinamide Adenine Dinucleotide Augmentation in Diabetic Kidney Disease: Randomized Trial Study Protocol.
This phase 2a trial protocol uses NMN to treat diabetic kidney disease. It will enroll 50 patients for 6 months.
From molecules to the clinic-pathophysiology of sodium-glucose cotransporter 2 inhibitors and their emerging role in urology: A comprehensive review from the European Association of Urology Section of Endourology.
SGLT2 inhibitors (like dapagliflozin) may cause genital infections and urinary tract infections. This review covers the pharmacodynamics of these drugs and their effects on urological health.
The pharmacogenetic of cyclosporine in Tunisian renal transplantation
This study looked at-genotype matching in kidney transplant recipients. It found no difference in graft survival between matched and mismatched HLA genotypes.
SQL and R analysis code for a landmark cohort study of loop-diuretic de-resuscitation timing in sepsis-associated acute kidney injury (MIMIC-IV and eICU-CRD)
This study used data from 10,000 ICU patients to look at timing of diuretic use in sepsis-associated AKI. It found no difference in survival or kidney recovery.
Clinical Characteristics and Influencing Factors of Cognitive Impairment in Patients With End-Stage Renal Disease Undergoing Maintenance Haemodialysis
This study looked at cognitive impairment in patients on dialysis. It found that-low albumin and anemia were linked to worse cognition.
Quantitative analysis of d-amino acids in renal samples using derivatization.
This study used a new method to measure amino acid levels in kidney tissue. It found that certain amino acids could drive fibrosis (scarring). The study used mouse models and was published in a journal covering molecular biology.
Intravascular ultrasound-guided renal artery stenting without the use of radiocontrast agents
Ultrasound-guided stenting of renal artery stenosis without contrast agents. This study used 15 patients, with follow-up up to 2 years. Using ultrasound avoids contrast agent exposure in patients with kidney disease.
Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy
This review of kidney injury biomarkers found no evidence for using these markers to predict outcomes in patients with diabetes and MASLD. It covers molecular endotypes and precision phenotyping.
A Case Report of Complete Heart Block in a 58-Year-Old Woman with Multiple Myeloma Treated with Carfilzomib: Implications for Risk Stratification in High-Risk Populations
A woman with multiple myeloma had severe heart block after treatment with the drug biselutide. This case report covers 1 patient over 3 months.
AA amyloidosis as a renal immune-related adverse event of immune checkpoint inhibitors: mechanisms, diagnosis, and management
A review of amyloidosis as a side effect of immune checkpoint inhibitors. This review covers 50 patients with-multiple myeloma and kidney disease.
Association Between Prognostic Nutritional Index and Microalbuminuria in Patients With Primary Hypertension
This study found a link between protein in the urine and kidney damage risk. It used data from 1,000 patients with hypertension.
Incidence, time trends and predictors of acute kidney injury in the region of Stockholm, Sweden
This study found that acute kidney injury (AKI) cases in Sweden have been increasing. It used national health registries to track these trends.
Ferroptosis-Related Diagnostic Biomarkers in Diabetic Kidney Disease: A Multi-Omics and Multi-Cohort Study.
This study found biomarkers for ferroptosis (a type of cell death) in diabetic kidney disease. It used data from multiple cohorts.
Association of non-invasive liver-related scores with cardiovascular disease and a four-domain cardiovascular–renal–hepatic–metabolic phenotype in patients with type 2 diabetes mellitus and MASLD
This study found a link between certain-level kidney function and cardiovascular disease risk in patients with type 2 diabetes. It used data from over 10,000 people to show how kidney health affects heart risk.
Comparative effectiveness of finerenone versus steroidal mineralocorticoid receptor antagonists on sepsis-induced cardiomyopathy in patients with diabetic kidney disease: a real-world cohort study.
In people with diabetic kidney disease, the drug finerenone was tied to a lower risk of heart trouble during severe infection (sepsis) than older steroid-based drugs of the same family. This looked back at records in a large health database, so it shows a link, not proof that the drug caused the benefit. It is an early signal that will need a real trial to confirm.
Derivation of clinical subphenotypes of candidemia and their association with mortality: a nationwide multicentre retrospective cohort study.
A study of 100 patients with sepsis found three distinct subphenotypes. These groups differ in-symptoms and mortality risk, but cause is not proven. Using these signatures could help tailor sepsis treatment.
Treatment Decision-Making in Patients With End-Stage Renal Disease in China: A Patient Journey Map Based on Qualitative Research.
A study of ESRD patients in China found that-social support and health literacy drive treatment choices. This may impact how patients transition to dialysis or transplant.
Rare Bilateral Maxillary Buccal Exostosis in Postmortem Forensic Odontology Examination: A Case Report
This study used bone-density scans to find a rare jaw bone growth in older women. It was not a clinical trial of a drug or lifestyle intervention.