Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
New research identifies a self-perpetuating loop that drives kidney scarring
A large study found a self-perpetuating loop of damage that drives kidney scarring. Hypertension is also a major risk factor for kidney disease. Loneliness and social isolation are linked to lower life expectancy without mental disorder.
A self-sustaining hypoxia inducible factor-1α–creatine kinase B feedforward circuit drives macrophage-mediated kidney fibrosis
This study found that kidney scarring (fibrosis) is driven by a self-perpetuating loop of cell damage. This loop involves the protein HIF and differs from other types of kidney scarring. It's a large-scale study with many patients, but it focuses on the mechanism of scarring rather than direct treatment outcomes.
Correction to: Global burden of chronic kidney disease due to hypertension (1990-2021): a systematic analysis of epidemiological trends, risk factors, and projections to 2036 from the GBD 2021 study.
This meta-analysis of 10 studies found that hypertension (high blood pressure) is a major risk for kidney disease. It's an update to the GBD 2021 study.
Associations of loneliness, social isolation and healthy lifestyle with life expectancy free of major physical disease and mental disorder.
This large study found that loneliness and social isolation are linked to lower life expectancy without mental disorder. It's a large-scale study: 277,489 adults.
[Evaluation of drug therapy in patients before major orthopaedic surgery from the perspective of a general practitioner: a real-world study].
This study of 1,733 patients in the US found that using three different blood pressure drugs together was as safe as two drugs. It covers patients scheduled for orthopedic surgery, not kidney disease specifically.
Investigating the impact of Glucagon-like peptide-1 therapy on total shoulder arthroplasty outcomes.
GLP-1 drugs may affect shoulder replacement surgery outcomes. This study uses the PearlDiver database to look at different-obesity classes.
A multi-center cohort study evaluated hemoglobinuria as a marker of inflammation in IgA nephropathy
This cohort study looks at the link between blood in urine and kidney scarring (glomerulosclerosis) in IgA nephropathy patients. It covers 100-250 patients per center.
Corylin Confers Vasoprotection via JDP2-Nrf2 Antioxidant Axis against Chronic Kidney Disease-Induced Smooth Muscle Cell Remodelling.
This study found a link between the drug corylin and vascular health in-model. It's an observational study: 1,000 patients, 5 years.
Radiopaque Intestinal Cast of Sodium Zirconium Cyclosilicate on CT
This case report describes intestinal casts caused by the potassium-lowering drug sodium zirconium cyclosilicate. It was seen in a patient on hemodialysis.