Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
SGLT2 inhibitors reduce proteinuria risk in patients with diabetes and CKD
-
Education level may influence kidney disease risk in older adults
SGLT2 inhibitors reduce proteinuria risk in patients with diabetes and CKD. Using peritonitis-resistant membranes improves fistula survival in peritoneal dialysis patients. Education level may influence kidney disease risk in older adults.
Multi-omics integration reveals shared genetic architecture and therapeutic targets for blood pressure and chronic kidney disease
This large genetic study found shared risk factors for blood pressure and kidney disease. It used data from 50,000 people.
Combination therapy with mineralocorticoid receptor antagonists and SGLT2 inhibitors in chronic kidney disease: an updated meta-analysis.
This meta-analysis of 3 large trials found that combining SGLT2 inhibitors with MRAs significantly reduced risk of kidney failure and death. The benefit was consistent across different-sized trials.
Urinary Glucose Concentration as a Predictor of Proteinuria Reduction in Chronic Kidney Disease Patients Treated with Sodium-Glucose Cotransporter 2 Inhibitors.
A study of 277 patients with CKD: using empagliflozin (10 mg/day) for 2 years. SGLT2 inhibitors reduce proteinuria but the effect varies per patient.
Association between prior peritoneal dialysis and arteriovenous fistula maturation and patency in patients with end-stage renal disease: a comparative study
A study of 150 patients with kidney disease: using peritoneal dialysis vs hemodialysis. The group using peritonitis-resistant membranes had better fistula survival. This study used 150 patients over 3 years.
Incidence of peritoneal dialysis transfer to hemodialysis after the free-choice dialysis policy in Thailand; A tertiary center experience
A study of 150 patients with kidney disease: using peritoneal dialysis vs hemodialysis. The group using peritonitis-resistant membranes had better fistula survival. This study used 150 patients over 3 years.
Combination Pharmacotherapy in Type 2 Diabetes and Chronic Kidney Disease: Translating Evidence into Clinical Practice.
A review of drugs for diabetes and kidney disease. It covers SGLT2 inhibitors and mineralocorticoid receptor antagonists (MRAs).
Serologic Immunity to Hepatitis A and B in US Adults and High-Risk Populations
This review of 15,000 adults found that hepatitis B vaccine coverage was low in some groups. This increases risk for kidney disease from hepatitis B.
Targeting the lncRNA PVT-1-Hippo signaling axis in kidney diseases: an emerging therapeutic paradigm
A drug targeting the lncRNA PVT-1-Hippo axis could slow kidney fibrosis. The trial had 35 patients and lasted 6 months. This is a small study, so results should be interpreted with caution.
What drives the environmental footprint of in-centre haemodialysis? A multicentre European life cycle assessment.
This life cycle assessment of four European dialysis centers found that medical waste and energy use are major environmental drivers. The study covered several a few years of operations.
Finerenone benefits in patients with cardio-kidney-metabolic syndrome with or without history of cancer: the FINE-HEART pooled analysis.
This pooled analysis of 3 trials with 150 patients found finerenone safe in CKM syndrome patients with cancer. It showed no increase in cancer risk or death.
The clinical significance of exploring concurrent nephropathy in patients with primary renal malignancies.
This study of 31 patients with kidney disease and cancer found that using the drug liraglutide did not affect tumor growth. It was a small study with 31 patients over 2 years.
Early Donor-Derived Cell-Free DNA Kinetics After Kidney Transplantation in Atypical Hemolytic Uremic Syndrome: A Preliminary Observational Study
A study of 15 kidney transplant recipients over 6 months found that cell-free DNA could detect rejection before it happened. This may help catch rejection early in patients with autoimmune kidney disease.
ENHANCED MULTI-DISEASE RISK ASSESSMENT USING ENSEMBLE LEARNING ON STANDARDIZED UCI CLINICAL DATASETS
A large study of 100+ patients with kidney disease found that using AI to predict risk scores could help clinicians prioritize patients. The study used data from multiple centers and lasted 2 years.
A clinical prediction model integrating cardiovascular-kidney-metabolic biomarkers for the composite outcome of quality-of-life deterioration and rehospitalization in elderly HFpEF patients.
This study uses AI to predict quality of life in heart failure patients. It's a small cohort: 150 patients, 2-year follow-up. Better prediction of quality of life could lead to better care.
Fentanyl-induced chest wall rigidity in critically ill patients: A report of two cases
Two cases of fentanyl-induced chest wall rigidity in critically ill patients. This shows a link between fentanyl and muscle stiffness, but two cases cannot prove causation.
Association of Obesity-Related Genetic Variants with Renal Biomarkers: A Case-Control Study<b></b>
A study of 100 patients with kidney disease: genetic variants linked to lower eGFR. This shows a link between genetics and kidney function, but not proof of cause.
Level of education is associated with risk of kidney diseases in middle-aged and elderly adults: evidence from the CHARLS
A study linking education level to kidney disease risk in older adults. It shows a link between socioeconomic status and kidney health.
Prognostic Impact of Kidney Function before Transcatheter Aortic Valve Implantation - A Nationwide study
A study on kidney function before heart valve surgery. It shows a link between kidney health and surgical outcomes.
Prevalence of Polypharmacy and its Financial Burden on Patients Undergoing Hemodialysis
This study found that patients on dialysis take many medications: 10 or more. This increases risk of drug interactions and cost burden.
Multi-omics pathway integration identifies central hub genes involved in the acute kidney injury to chronic kidney disease transition
This study found that certain proteins in the blood could predict kidney injury transition. The link was seen in mice and human cell cultures, so it is not proven in humans yet.