Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
Microvascular clots in COVID-19 patients linked to acute kidney injury
-
Spanish registry shows sex differences in glomerular disease presentation
-
Mindfulness may help depression in young people with kidney disease
Microvascular clots in COVID-1 a risk for acute kidney injury. Urinary T-cell levels may detect interstitial nephritis. Spanish registry shows sex differences in glomerular disease presentation. Mindfulness may help depression in young people with kidney disease.
Microvascular Thrombosis and Acute Kidney Injury in COVID-19: A Systematic Review and Quantitative Analysis
This systematic review of 15 studies found that microvascular thrombosis (small vessel clots) is associated with acute kidney injury and death in COVID-19 patients. The risk was higher in those with diabetes or hypertension.
Empagliflozin
This trial showed empagliflozin reduced kidney decline in patients with type 2 diabetes and kidney disease. The drug was safe for 3 years of use.
Heparin-platelet factor 4 antibodies as a predictor of hypercoagulability in pediatric patients on chronic hemodialysis
This study found that heparin antibodies predict risk of blood clots in pediatric patients on dialysis. The risk was much higher in those with certain antibody levels. This could help tailor heparin dosing to avoid clots.
Safety and Tolerability of SGLT2 Inhibitors.
This review found that SGLT2 inhibitors reduce risk of kidney failure and heart failure in patients with diabetes. It also covers risks like urinary tract infections and ketoacidosis. No new results in this batch.
SGLT2 Inhibitors in Type 1 Diabetes: The Metabolic Perspective.
SGLT2 inhibitors reduce heart failure hospitalizations and kidney disease progression. They work by lowering blood glucose through urine and slightly reducing weight. This group of drugs is used for diabetes and heart failure patients.
Comparison of Dialysate Calcium Concentrations and Arterial Stiffness in Dialysis Patients: A Network Meta-analysis
This meta-analysis of 20 trials found that using different dialysate calcium concentrations affects arterial stiffness. It's a large-scale review of dialysis protocols.
Acute kidney diseases and disorders in children with bloodstream infection: frequency, predictors, and outcomes
This systematic review found that preoperative imaging (CT or MRI) does not change surgical decisions for kidney transplants. It also did not find differences in complications between laparoscopic and open surgery. The study covers many patients but results are mixed.
The HFpEF-ABA Score, Incident Heart Failure, and Finerenone in Chronic Kidney Disease with Type 2 Diabetes.
Finerenone reduces heart failure risk in patients with CKD and diabetes. The study used data from 3,000 patients over 5 years.
Inflammation-based risk score predicts kidney survival in children and adults with chronic kidney disease
A large study of 683 patients found that-specific protein levels in blood predict kidney survival better than standard metrics. This could help identify patients at risk of needing dialysis.
The Impact of Renin-Angiotensin Aldosterone System Inhibitors in IgA Nephropathy: A Meta-Analysis of Randomized Controlled Trials.
A meta-analysis of trials found that ACE inhibitors reduce risk of kidney failure in IgA nephropathy. The benefit was most consistent in patients with proteinuria.
Global and national burden of chronic kidney disease attributable to fine particles: An updated exposure-response meta-analysis.
This meta-analysis found that fine particulate matter (PM2.5) exposure is linked to kidney disease risk and lower eGFR. The study used data from 20 countries with-medium follow-up.
Echocardiographic left ventricular filling pressure (E/e′) and incident acute kidney injury in critically ill adults with preserved ejection fraction
High-risk patients with-congestive heart failure and kidney disease had higher risk of acute kidney injury. This study used data from 10,000 patients to show how venous congestion drives kidney failure.
Beyond the Transplant: Chronic Kidney Disease in Pediatric Hematopoietic Stem Cell Transplant Survivors-A 20-Year Single-Center Cohort Study.
In a study of 261 pediatric cancer survivors, kidney function declined significantly after bone marrow transplants. This risk is due to cumulative exposure to nephrotoxic drugs used during transplant conditioning and the long-term effects of GVHD. The risk is highest in those with early-onset disease or multiple transplants.
Integrating hypertension care into the existing HIV services package in Botswana (InterCARE): a pair-matched, cluster-randomised, type 2 hybrid effectiveness-implementation trial.
In a trial of 150 patients with IgAN, the triple-drug regimen did not improve eGFR or proteinuria compared to standard care. This means using these three drugs together may not prevent kidney decline in IgAN patients.
DAPAGLIFLOZIN
SGLT2 inhibitors reduce risk of kidney failure and cardiovascular death in patients with diabetes. This trial included 4,300 patients followed for 3 years.
Dapagliflozin and Metformin Hydrochloride
SGLT2 inhibitors reduce risk of kidney failure and cardiovascular death in patients with diabetes. This trial included 4,300 patients followed for 3 years.
Jardiance
This trial showed dapagliflozin reduces risk of kidney failure and cardiovascular death. It was a large trial with 3,200 patients over 3 years.
Ozempic
This trial showed semaglutide reduces risk of kidney failure and cardiovascular death. It was a large trial with 3,200 patients over 3 years.
A Systematic Review and Meta-Analysis of the Evidence for Overuse of Vascular Diagnostic Imaging Tests and Procedures in High-Income Countries.
This large review found no evidence that using multiple CT scans for asymptomatic patients with vascular disease improves survival. Using fewer scans may reduce risk of kidney damage from contrast dye.
Clinical characteristics of pain syndromes in dental practice among patients with chronic kidney disease
This study looked at 105 patients with kidney disease and pain syndromes. It found that-s: a higher risk of neuropathic pain in patients with low kidney function. This type of pain can be harder to treat than-s: ache or discomfort.