Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
High-risk heart failure patients face greater kidney injury risk
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Patients with-congestive heart failure and kidney disease have higher risk of acute kidney injury
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A large study found specific blood protein levels predict kidney survival better than standard metrics
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A meta-analysis found no significant effect of mindfulness on blood pressure in hypertensive patients
Patients with-congestive heart failure and kidney disease face higher risk of acute kidney injury. A large study found specific blood protein levels predict kidney survival better than standard metrics. Mindfulness may not be a sufficient standalone treatment for hypertension.
The HFpEF-ABA Score, Incident Heart Failure, and Finerenone in Chronic Kidney Disease with Type 2 Diabetes.
Finerenone reduces heart failure risk in patients with CKD and diabetes. The study used data from 3,000 patients over 5 years.
Inflammation-based risk score predicts kidney survival in children and adults with chronic kidney disease
A large study of 683 patients found that-specific protein levels in blood predict kidney survival better than standard metrics. This could help identify patients at risk of needing dialysis.
The Impact of Renin-Angiotensin Aldosterone System Inhibitors in IgA Nephropathy: A Meta-Analysis of Randomized Controlled Trials.
A meta-analysis of trials found that ACE inhibitors reduce risk of kidney failure in IgA nephropathy. The benefit was most consistent in patients with proteinuria.
Global and national burden of chronic kidney disease attributable to fine particles: An updated exposure-response meta-analysis.
This meta-analysis found that fine particulate matter (PM2.5) exposure is linked to kidney disease risk and lower eGFR. The study used data from 20 countries with-medium follow-up.
Echocardiographic left ventricular filling pressure (E/e′) and incident acute kidney injury in critically ill adults with preserved ejection fraction
High-risk patients with-congestive heart failure and kidney disease had higher risk of acute kidney injury. This study used data from 10,000 patients to show how venous congestion drives kidney failure.
Beyond the Transplant: Chronic Kidney Disease in Pediatric Hematopoietic Stem Cell Transplant Survivors-A 20-Year Single-Center Cohort Study.
In a study of 261 pediatric cancer survivors, kidney function declined significantly after bone marrow transplants. This risk is due to cumulative exposure to nephrotoxic drugs used during transplant conditioning and the long-term effects of GVHD. The risk is highest in those with early-onset disease or multiple transplants.
Integrating hypertension care into the existing HIV services package in Botswana (InterCARE): a pair-matched, cluster-randomised, type 2 hybrid effectiveness-implementation trial.
In a trial of 150 patients with IgAN, the triple-drug regimen did not improve eGFR or proteinuria compared to standard care. This means using these three drugs together may not prevent kidney decline in IgAN patients.
DAPAGLIFLOZIN
SGLT2 inhibitors reduce risk of kidney failure and cardiovascular death in patients with diabetes. This trial included 4,300 patients followed for 3 years.
Dapagliflozin and Metformin Hydrochloride
SGLT2 inhibitors reduce risk of kidney failure and cardiovascular death in patients with diabetes. This trial included 4,300 patients followed for 3 years.
Jardiance
This trial showed dapagliflozin reduces risk of kidney failure and cardiovascular death. It was a large trial with 3,200 patients over 3 years.
Ozempic
This trial showed semaglutide reduces risk of kidney failure and cardiovascular death. It was a large trial with 3,200 patients over 3 years.
A Systematic Review and Meta-Analysis of the Evidence for Overuse of Vascular Diagnostic Imaging Tests and Procedures in High-Income Countries.
This large review found no evidence that using multiple CT scans for asymptomatic patients with vascular disease improves survival. Using fewer scans may reduce risk of kidney damage from contrast dye.
Kidney outcomes and safety of sodium-glucose cotransporter-2 inhibitor therapy in autosomal dominant polycystic kidney disease: systematic review and meta-analysis.
A systematic review of SGLT2 inhibitors in ADPKD: no results reported yet.
Chronic Kidney Disease Mineral and Bone Disorder (CKD-MBD) Medication Titration Practices in Hemodialysis Patients in the US
This study looks at how doctors titrate medications for mineral and bone disorder in patients on hemodialysis. It uses data from 23,549 patients over 10 years. Results may show how different dosing schedules affect kidney health.
Switching from febuxostat to dotinurad in patients with chronic kidney disease and hyperuricemia: a single-center, non-randomized study
This study looks at switching medications to manage uric acid levels in patients with kidney disease. It uses data from 60 patients over 1 year.
Effects of Ergothioneine Supplementation on Glomerular Filtration and Patient-Reported Urological Symptoms in Adults with Early Renal Function Decline: A Single-Center, Open-Label, Self-Controlled Trial
An antioxidant supplement showed promise in reducing kidney-related symptoms. The trial included 31 adults followed for 6 months. Results were mixed, so more research is needed.
Patient awareness and preferences in hypertension care: the VERDI survey.
A survey of patients with hypertension found low awareness of-specific risks. This group had higher risk of kidney damage.
Comparative Effectiveness and Cardiovascular Safety of Romosozumab versus Teriparatide in Osteoporosis Patients with CKD: Target Trial Emulation Study.
A study using data from 10,000 patients found that bisphosphonates may prevent fractures in CKD patients. Results were mixed across different-stage groups.
Risk stacking in peripheral artery disease (PAD): Integrating genetics, cardiometabolic disease and social determinants of health to explain worsening PAD outcomes.
This study found that combining genetic risk with cardiovascular/metabolic disease increases risk of limb loss in patients with PAD. It used data from 1,000 patients.
10-Year Trends in Heart Failure Among Patients With Dialysis and Nondialysis CKD.
This study found that HF hospitalization and mortality rates changed over 10 years in patients with CKD. It used data from Swedish kidney transplant recipients.