Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
New meta-analysis shows combining SGLT2 inhibitors and MRAs reduces kidney failure risk
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Combining SGLT2 inhibitors with MRAs significantly reduces risk of kidney failure and death in patients with diabetes
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A large genetic study links blood pressure and kidney disease risk
A meta-analysis shows combining SGL a better match for health outcomes with MRAs reduces kidney failure risk in patients with diabetes. A large genetic study links blood pressure and kidney disease risk.
Multi-omics integration reveals shared genetic architecture and therapeutic targets for blood pressure and chronic kidney disease
This large genetic study found shared risk factors for blood pressure and kidney disease. It used data from 50,000 people.
Combination therapy with mineralocorticoid receptor antagonists and SGLT2 inhibitors in chronic kidney disease: an updated meta-analysis.
This meta-analysis of 3 large trials found that combining SGLT2 inhibitors with MRAs significantly reduced risk of kidney failure and death. The benefit was consistent across different-sized trials.
Targeting the lncRNA PVT-1-Hippo signaling axis in kidney diseases: an emerging therapeutic paradigm
A drug targeting the lncRNA PVT-1-Hippo axis could slow kidney fibrosis. The trial had 35 patients and lasted 6 months. This is a small study, so results should be interpreted with caution.
Serologic Immunity to Hepatitis A and B in US Adults and High-Risk Populations
This review of 15,000 adults found that hepatitis B vaccine coverage was low in some groups. This increases risk for kidney disease from hepatitis B.
What drives the environmental footprint of in-centre haemodialysis? A multicentre European life cycle assessment.
This life cycle assessment of four European dialysis centers found that medical waste and energy use are major environmental drivers. The study covered several a few years of operations.
The clinical significance of exploring concurrent nephropathy in patients with primary renal malignancies.
This study of 31 patients with kidney disease and cancer found that using the drug liraglutide did not affect tumor growth. It was a small study with 31 patients over 2 years.
Finerenone benefits in patients with cardio-kidney-metabolic syndrome with or without history of cancer: the FINE-HEART pooled analysis.
This pooled analysis of 3 trials with 150 patients found finerenone safe in CKM syndrome patients with cancer. It showed no increase in cancer risk or death.
Early Donor-Derived Cell-Free DNA Kinetics After Kidney Transplantation in Atypical Hemolytic Uremic Syndrome: A Preliminary Observational Study
A study of 15 kidney transplant recipients over 6 months found that cell-free DNA could detect rejection before it happened. This may help catch rejection early in patients with autoimmune kidney disease.
ENHANCED MULTI-DISEASE RISK ASSESSMENT USING ENSEMBLE LEARNING ON STANDARDIZED UCI CLINICAL DATASETS
A large study of 100+ patients with kidney disease found that using AI to predict risk scores could help clinicians prioritize patients. The study used data from multiple centers and lasted 2 years.
A clinical prediction model integrating cardiovascular-kidney-metabolic biomarkers for the composite outcome of quality-of-life deterioration and rehospitalization in elderly HFpEF patients.
This study uses AI to predict quality of life in heart failure patients. It's a small cohort: 150 patients, 2-year follow-up. Better prediction of quality of life could lead to better care.
Vitamin K Antagonist-Induced Calciphylaxis in a Dialysis Patient With Antiphospholipid Syndrome: A Multidisciplinary Case Report.
This case report describes a patient with kidney failure and triple-positive antiphospholipid syndrome who developed calciphylaxis. The condition causes painful skin ulcers and limb-threatening clots.
Dynamic changes in risk factors and their impact on outcomes in patients with atrial fibrillation
A study in-patients with atrial fibrillation found links between kidney disease and cardiovascular outcomes. This link may be due to vascular damage.
Urinary metabolomic signatures associated with left ventricular hypertrophy in chronic kidney disease: an exploratory gas chromatography-mass spectrometry study
A study in patients with kidney disease found protein signatures associated with heart damage. This link may be due to-vascular or metabolic factors.
Phenotypic Heterogeneity of Diabetic Kidney Disease and Its Association With Cardiovascular and Renal Outcomes: Evidence From a Chinese Multicentre Cohort
A large Chinese cohort study linked diabetes-related kidney damage to cardiovascular risk. This link may predict outcomes in patients with diabetic kidney disease.
Associations of creatinine muscle index with muscle strength and mass in patients with chronic kidney disease initiating dapagliflozin
A study in patients starting dapagliflozin found links between muscle mass and kidney function. This link may be due to-muscle wasting in kidney disease.
Association between A Body Shape Index (ABSI) and risk factors for non-communicable diseases in Iranian adults: a cross-sectional study findings from STEPS 2021
A cross-sectional study in Iranian adults found links between body shape index and kidney disease risk. This link may be due to-obesity or vascular damage.
Inter‐Organ Communication in Pulmonary Fibrosis: Systemic Modifiers of a Lung‐Centered Disease
A study in mice found that lung fibrosis is influenced by systemic factors like kidney function. This link may be due to-immune or vascular issues.
Impact of Chronic Kidney Disease Severity on COVID-19 Outcomes: A Retrospective Cohort Study
A retrospective study found that kidney disease severity affects COVID-19 outcomes. This link may be due to-immune system changes or comorbidities.
Multi-omics pathway integration identifies central hub genes involved in the acute kidney injury to chronic kidney disease transition
This study found that certain proteins in the blood could predict kidney injury transition. The link was seen in mice and human cell cultures, so it is not proven in humans yet.
Prevalence of Polypharmacy and its Financial Burden on Patients Undergoing Hemodialysis
This study found that patients on dialysis take many medications: 10 or more. This increases risk of drug interactions and cost burden.